node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70728.1 | ABK72227.1 | MSMEG_2505 | MSMEG_2504 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 0.998 |
ABK70728.1 | ABK72982.1 | MSMEG_2505 | MSMEG_3285 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydrogenase; Identified by match to protein family HMM PF00180. | 0.991 |
ABK70728.1 | ABK73595.1 | MSMEG_2505 | MSMEG_5826 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | Pyruvate decarboxylase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.893 |
ABK70728.1 | ilvC | MSMEG_2505 | MSMEG_2374 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.915 |
ABK70728.1 | leuA | MSMEG_2505 | MSMEG_6271 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.972 |
ABK70728.1 | leuB | MSMEG_2505 | MSMEG_2379 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.992 |
ABK70728.1 | leuC | MSMEG_2505 | MSMEG_2387 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.907 |
ABK70728.1 | leuC-2 | MSMEG_2505 | MSMEG_6854 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.903 |
ABK70728.1 | leuD | MSMEG_2505 | MSMEG_2388 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.996 |
ABK70728.1 | leuD-2 | MSMEG_2505 | MSMEG_6853 | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.995 |
ABK72227.1 | ABK70728.1 | MSMEG_2504 | MSMEG_2505 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydratase large subunit; Identified by match to protein family HMM PF00330. | 0.998 |
ABK72227.1 | ABK72982.1 | MSMEG_2504 | MSMEG_3285 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Identified by match to protein family HMM PF00180. | 0.975 |
ABK72227.1 | ABK73595.1 | MSMEG_2504 | MSMEG_5826 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | Pyruvate decarboxylase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.882 |
ABK72227.1 | ilvC | MSMEG_2504 | MSMEG_2374 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.857 |
ABK72227.1 | leuA | MSMEG_2504 | MSMEG_6271 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.965 |
ABK72227.1 | leuB | MSMEG_2504 | MSMEG_2379 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.972 |
ABK72227.1 | leuC | MSMEG_2504 | MSMEG_2387 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.979 |
ABK72227.1 | leuC-2 | MSMEG_2504 | MSMEG_6854 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.995 |
ABK72227.1 | leuD | MSMEG_2504 | MSMEG_2388 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.901 |
ABK72227.1 | leuD-2 | MSMEG_2504 | MSMEG_6853 | 3-isopropylmalate dehydratase small subunit; Identified by match to protein family HMM TIGR02087; Belongs to the LeuD family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.908 |