node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK73076.1 | ABK74137.1 | MSMEG_0004 | MSMEG_0002 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | 6-phosphogluconate dehydrogenase, decarboxylating; Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. | 0.966 |
ABK73076.1 | dnaA | MSMEG_0004 | MSMEG_6947 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | 0.417 |
ABK73076.1 | dnaN | MSMEG_0004 | MSMEG_0001 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.940 |
ABK73076.1 | gyrA | MSMEG_0004 | MSMEG_0006 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.588 |
ABK73076.1 | gyrB | MSMEG_0004 | MSMEG_0005 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.724 |
ABK73076.1 | recF | MSMEG_0004 | MSMEG_0003 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.960 |
ABK73076.1 | recO | MSMEG_0004 | MSMEG_4491 | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.454 |
ABK74137.1 | ABK73076.1 | MSMEG_0002 | MSMEG_0004 | 6-phosphogluconate dehydrogenase, decarboxylating; Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | 0.966 |
ABK74137.1 | dnaN | MSMEG_0002 | MSMEG_0001 | 6-phosphogluconate dehydrogenase, decarboxylating; Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.829 |
ABK74137.1 | gyrA | MSMEG_0002 | MSMEG_0006 | 6-phosphogluconate dehydrogenase, decarboxylating; Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.580 |
ABK74137.1 | gyrB | MSMEG_0002 | MSMEG_0005 | 6-phosphogluconate dehydrogenase, decarboxylating; Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.616 |
ABK74137.1 | recF | MSMEG_0002 | MSMEG_0003 | 6-phosphogluconate dehydrogenase, decarboxylating; Identified by match to protein family HMM PF00393; match to protein family HMM PF03446; match to protein family HMM TIGR00872. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.906 |
dnaA | ABK73076.1 | MSMEG_6947 | MSMEG_0004 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | RecF-gyrB intergenic region protein; identified by match to protein family HMM PF05258; Belongs to the UPF0232 family. | 0.417 |
dnaA | dnaN | MSMEG_6947 | MSMEG_0001 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.999 |
dnaA | gyrA | MSMEG_6947 | MSMEG_0006 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.808 |
dnaA | gyrB | MSMEG_6947 | MSMEG_0005 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.750 |
dnaA | recF | MSMEG_6947 | MSMEG_0003 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.971 |
dnaA | recR | MSMEG_6947 | MSMEG_6279 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.751 |
dnaA | rnpA | MSMEG_6947 | MSMEG_6945 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.892 |
dnaA | rpmH | MSMEG_6947 | MSMEG_6946 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Ribosomal protein L34; Identified by match to protein family HMM PF00468; match to protein family HMM TIGR01030; Belongs to the bacterial ribosomal protein bL34 family. | 0.971 |