node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71345.1 | ABK75196.1 | MSMEG_5250 | MSMEG_5248 | CalR9 protein. | acyl-[ACP] desaturase; Identified by match to protein family HMM PF03405. | 0.464 |
ABK71345.1 | coaA | MSMEG_5250 | MSMEG_5252 | CalR9 protein. | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.750 |
ABK71345.1 | glyA | MSMEG_5250 | MSMEG_5249 | CalR9 protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.672 |
ABK74560.1 | coaA | MSMEG_0909 | MSMEG_5252 | acyl-ACP thioesterase superfamily protein; Identified by match to protein family HMM PF01643. | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.473 |
ABK75196.1 | ABK71345.1 | MSMEG_5248 | MSMEG_5250 | acyl-[ACP] desaturase; Identified by match to protein family HMM PF03405. | CalR9 protein. | 0.464 |
ABK75196.1 | coaA | MSMEG_5248 | MSMEG_5252 | acyl-[ACP] desaturase; Identified by match to protein family HMM PF03405. | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.415 |
ABK75196.1 | glyA | MSMEG_5248 | MSMEG_5249 | acyl-[ACP] desaturase; Identified by match to protein family HMM PF03405. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.660 |
coaA | ABK71345.1 | MSMEG_5252 | MSMEG_5250 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | CalR9 protein. | 0.750 |
coaA | ABK74560.1 | MSMEG_5252 | MSMEG_0909 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | acyl-ACP thioesterase superfamily protein; Identified by match to protein family HMM PF01643. | 0.473 |
coaA | ABK75196.1 | MSMEG_5252 | MSMEG_5248 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | acyl-[ACP] desaturase; Identified by match to protein family HMM PF03405. | 0.415 |
coaA | coaBC | MSMEG_5252 | MSMEG_3054 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.982 |
coaA | coaD | MSMEG_5252 | MSMEG_2414 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.990 |
coaA | coaX | MSMEG_5252 | MSMEG_6096 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Bvg accessory factor family protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.979 |
coaA | glyA | MSMEG_5252 | MSMEG_5249 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.591 |
coaA | panC | MSMEG_5252 | MSMEG_6097 | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.945 |
coaBC | coaA | MSMEG_3054 | MSMEG_5252 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.982 |
coaBC | coaD | MSMEG_3054 | MSMEG_2414 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.994 |
coaBC | coaX | MSMEG_3054 | MSMEG_6096 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Bvg accessory factor family protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.972 |
coaBC | panC | MSMEG_3054 | MSMEG_6097 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.955 |
coaD | coaA | MSMEG_2414 | MSMEG_5252 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. | 0.990 |