node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MXAN_0318 | bioB | MXAN_0318 | MXAN_1257 | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.995 |
MXAN_0318 | bioD | MXAN_0318 | MXAN_1259 | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.996 |
MXAN_0318 | bioF | MXAN_0318 | MXAN_1258 | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.985 |
MXAN_0318 | birA | MXAN_0318 | MXAN_4152 | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.479 |
MXAN_6777 | bioB | MXAN_6777 | MXAN_1257 | Putative succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.704 |
MXAN_6777 | folA | MXAN_6777 | MXAN_5943 | Putative succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.654 |
MXAN_6777 | tmk | MXAN_6777 | MXAN_3412 | Putative succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.687 |
MXAN_6777 | tmk-2 | MXAN_6777 | MXAN_2582 | Putative succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.741 |
MXAN_6777 | xseA | MXAN_6777 | MXAN_4647 | Putative succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.701 |
bioB | MXAN_0318 | MXAN_1257 | MXAN_0318 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.995 |
bioB | MXAN_6777 | MXAN_1257 | MXAN_6777 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Putative succinyl-diaminopimelate desuccinylase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687. | 0.704 |
bioB | bioD | MXAN_1257 | MXAN_1259 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioB | bioF | MXAN_1257 | MXAN_1258 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.953 |
bioB | birA | MXAN_1257 | MXAN_4152 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.947 |
bioB | folA | MXAN_1257 | MXAN_5943 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.732 |
bioB | rocD | MXAN_1257 | MXAN_7377 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Ornithine aminotransferase; Identified by similarity to SP:P38021; match to protein family HMM PF00202; match to protein family HMM TIGR01885; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.716 |
bioB | tmk | MXAN_1257 | MXAN_3412 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.761 |
bioB | tmk-2 | MXAN_1257 | MXAN_2582 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.761 |
bioB | xseA | MXAN_1257 | MXAN_4647 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.785 |
bioD | MXAN_0318 | MXAN_1259 | MXAN_0318 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P22805; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.996 |