| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MXAN_1393 | MXAN_3015 | MXAN_1393 | MXAN_3015 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | 0.677 |
| MXAN_1393 | MXAN_3016 | MXAN_1393 | MXAN_3016 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Putative chaperone protein DnaK; Identified by similarity to SP:Q98DD1; match to protein family HMM PF00012; Belongs to the heat shock protein 70 family. | 0.745 |
| MXAN_1393 | dnaJ | MXAN_1393 | MXAN_0750 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.835 |
| MXAN_1393 | groL | MXAN_1393 | MXAN_4467 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.714 |
| MXAN_1393 | groL-2 | MXAN_1393 | MXAN_4895 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.714 |
| MXAN_1393 | groS | MXAN_1393 | MXAN_4894 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.696 |
| MXAN_1393 | grpE | MXAN_1393 | MXAN_6672 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.638 |
| MXAN_1393 | grpE-2 | MXAN_1393 | MXAN_4331 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Putative co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of A [...] | 0.638 |
| MXAN_1393 | hslU | MXAN_1393 | MXAN_3013 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.716 |
| MXAN_1393 | hslV | MXAN_1393 | MXAN_3012 | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | Heat shock protein HslVU, ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.728 |
| MXAN_3015 | MXAN_1393 | MXAN_3015 | MXAN_1393 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | 0.677 |
| MXAN_3015 | MXAN_3016 | MXAN_3015 | MXAN_3016 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Putative chaperone protein DnaK; Identified by similarity to SP:Q98DD1; match to protein family HMM PF00012; Belongs to the heat shock protein 70 family. | 0.893 |
| MXAN_3015 | groL | MXAN_3015 | MXAN_4467 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.617 |
| MXAN_3015 | groL-2 | MXAN_3015 | MXAN_4895 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.617 |
| MXAN_3015 | groS | MXAN_3015 | MXAN_4894 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.568 |
| MXAN_3015 | grpE | MXAN_3015 | MXAN_6672 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.670 |
| MXAN_3015 | grpE-2 | MXAN_3015 | MXAN_4331 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Putative co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of A [...] | 0.670 |
| MXAN_3015 | hslU | MXAN_3015 | MXAN_3013 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.737 |
| MXAN_3015 | hslV | MXAN_3015 | MXAN_3012 | DnaJ domain protein; Identified by match to protein family HMM PF00226; match to protein family HMM PF00515; match to protein family HMM PF07719. | Heat shock protein HslVU, ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.654 |
| MXAN_3016 | MXAN_1393 | MXAN_3016 | MXAN_1393 | Putative chaperone protein DnaK; Identified by similarity to SP:Q98DD1; match to protein family HMM PF00012; Belongs to the heat shock protein 70 family. | ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Identified by match to protein family HMM PF02518. | 0.745 |
STRING v12.5 is now available!
