birA protein (Myxococcus xanthus) - STRING interaction network

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birA

BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (334 aa)

Predicted Functional Partners:

coaX

0.955

bioB

0.947

pyc

0.934

MXAN_2559

0.929

MXAN_0564

0.925

pccB

0.905

pccA

0.894

bioF

0.891

MXAN_3498

0.843

MXAN_3759

0.831

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_0564	birA	MXAN_0564	MXAN_4152	Conserved hypothetical protein; Identified by similarity to GB:BAB49832.1.	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.925
MXAN_0564	pyc	MXAN_0564	MXAN_3881	Conserved hypothetical protein; Identified by similarity to GB:BAB49832.1.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.423
MXAN_2559	birA	MXAN_2559	MXAN_4152	Peptidase family M22, nonpeptidase-like protein; Identified by match to protein family HMM PF00814.	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.929
MXAN_3498	birA	MXAN_3498	MXAN_4152	tRNA nucleotidyltransferase/poly(A) polymerase family protein; Identified by similarity to PDB:1MIV_A.0; match to protein family HMM PF01743.	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.843
MXAN_3759	birA	MXAN_3759	MXAN_4152	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.831
MXAN_3759	pccA	MXAN_3759	MXAN_1111	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	propionyl-CoA carboxylase, alpha subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.975
MXAN_3759	pyc	MXAN_3759	MXAN_3881	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.825
bioB	bioF	MXAN_1257	MXAN_1258	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	0.953
bioB	birA	MXAN_1257	MXAN_4152	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.947
bioB	pyc	MXAN_1257	MXAN_3881	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.490
bioF	bioB	MXAN_1258	MXAN_1257	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.953
bioF	birA	MXAN_1258	MXAN_4152	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.891
birA	MXAN_0564	MXAN_4152	MXAN_0564	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Conserved hypothetical protein; Identified by similarity to GB:BAB49832.1.	0.925
birA	MXAN_2559	MXAN_4152	MXAN_2559	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Peptidase family M22, nonpeptidase-like protein; Identified by match to protein family HMM PF00814.	0.929
birA	MXAN_3498	MXAN_4152	MXAN_3498	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	tRNA nucleotidyltransferase/poly(A) polymerase family protein; Identified by similarity to PDB:1MIV_A.0; match to protein family HMM PF01743.	0.843
birA	MXAN_3759	MXAN_4152	MXAN_3759	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	0.831
birA	bioB	MXAN_4152	MXAN_1257	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.947
birA	bioF	MXAN_4152	MXAN_1258	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	0.891
birA	coaX	MXAN_4152	MXAN_4151	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Putative transcriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.	0.955
birA	pccA	MXAN_4152	MXAN_1111	BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	propionyl-CoA carboxylase, alpha subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.894