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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MXAN_4223Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. (259 aa)    
Predicted Functional Partners:
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 
 0.925
hisA
Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.
 
  
 0.896
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475; Belongs to the imidazoleglycerol-phosphate dehydratase family.
 
  
 0.893
hisIE
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase; Identified by similarity to SP:P06989; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.889
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.887
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.872
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
   
 0.865
hisC-2
Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155.
 
  
 0.839
MXAN_4706
Conserved hypothetical protein TIGR00255; Identified by similarity to GB:AAR35615.1; match to protein family HMM PF03755; match to protein family HMM TIGR00255.
 
 
    0.766
nusG
Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination.
   
 
 0.644
Your Current Organism:
Myxococcus xanthus
NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622
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