hisH protein (Myxococcus xanthus) - STRING interaction network

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hisH

Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa)

Predicted Functional Partners:

hisIE

0.999

hisF

0.999

hisB

0.999

hisA

0.999

hisD

0.993

hisG

0.993

hisC-2

0.986

hisC

0.884

MXAN_4223

0.872

purH

0.861

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_4223	hisA	MXAN_4223	MXAN_4226	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	0.896
MXAN_4223	hisB	MXAN_4223	MXAN_4225	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475; Belongs to the imidazoleglycerol-phosphate dehydratase family.	0.893
MXAN_4223	hisC	MXAN_4223	MXAN_4038	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.577
MXAN_4223	hisC-2	MXAN_4223	MXAN_4228	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155.	0.839
MXAN_4223	hisD	MXAN_4223	MXAN_4229	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.925
MXAN_4223	hisF	MXAN_4223	MXAN_4224	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.887
MXAN_4223	hisG	MXAN_4223	MXAN_4230	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.	0.865
MXAN_4223	hisH	MXAN_4223	MXAN_4227	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.872
MXAN_4223	hisIE	MXAN_4223	MXAN_4222	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase; Identified by similarity to SP:P06989; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	0.889
hisA	MXAN_4223	MXAN_4226	MXAN_4223	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	0.896
hisA	hisB	MXAN_4226	MXAN_4225	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475; Belongs to the imidazoleglycerol-phosphate dehydratase family.	0.998
hisA	hisC	MXAN_4226	MXAN_4038	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.858
hisA	hisC-2	MXAN_4226	MXAN_4228	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155.	0.987
hisA	hisD	MXAN_4226	MXAN_4229	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.	0.998
hisA	hisF	MXAN_4226	MXAN_4224	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.999
hisA	hisG	MXAN_4226	MXAN_4230	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.	0.993
hisA	hisH	MXAN_4226	MXAN_4227	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.999
hisA	hisIE	MXAN_4226	MXAN_4222	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase; Identified by similarity to SP:P06989; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.	0.999
hisA	purH	MXAN_4226	MXAN_2914	Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355.	0.539
hisB	MXAN_4223	MXAN_4225	MXAN_4223	Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Putative histidinol-phosphate phosphatase; Assignment based on phylogenetic profiling and gene location; identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.	0.893

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