| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MXAN_1443 | MXAN_3551 | MXAN_1443 | MXAN_3551 | Mg-chelatase subunits D/I family, ComM subfamily protein; Identified by match to protein family HMM PF01078; match to protein family HMM TIGR00368. | Conserved hypothetical protein TIGR00252; Identified by similarity to SP:Q8A5K3; match to protein family HMM PF02021; match to protein family HMM TIGR00252; Belongs to the UPF0102 family. | 0.811 |
| MXAN_1443 | ruvC | MXAN_1443 | MXAN_4973 | Mg-chelatase subunits D/I family, ComM subfamily protein; Identified by match to protein family HMM PF01078; match to protein family HMM TIGR00368. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.706 |
| MXAN_1443 | topA | MXAN_1443 | MXAN_3002 | Mg-chelatase subunits D/I family, ComM subfamily protein; Identified by match to protein family HMM PF01078; match to protein family HMM TIGR00368. | Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...] | 0.601 |
| MXAN_3551 | MXAN_1443 | MXAN_3551 | MXAN_1443 | Conserved hypothetical protein TIGR00252; Identified by similarity to SP:Q8A5K3; match to protein family HMM PF02021; match to protein family HMM TIGR00252; Belongs to the UPF0102 family. | Mg-chelatase subunits D/I family, ComM subfamily protein; Identified by match to protein family HMM PF01078; match to protein family HMM TIGR00368. | 0.811 |
| MXAN_3551 | ruvC | MXAN_3551 | MXAN_4973 | Conserved hypothetical protein TIGR00252; Identified by similarity to SP:Q8A5K3; match to protein family HMM PF02021; match to protein family HMM TIGR00252; Belongs to the UPF0102 family. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.607 |
| MXAN_4974 | ruvA | MXAN_4974 | MXAN_4972 | Conserved hypothetical protein TIGR01033; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.878 |
| MXAN_4974 | ruvC | MXAN_4974 | MXAN_4973 | Conserved hypothetical protein TIGR01033; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.828 |
| cas3 | ruvC | MXAN_7020 | MXAN_4973 | CRISPR-associated helicase Cas3; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR01587. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.587 |
| recX | ruvA | MXAN_1997 | MXAN_4972 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.436 |
| recX | ruvC | MXAN_1997 | MXAN_4973 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.630 |
| recX | topA | MXAN_1997 | MXAN_3002 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...] | 0.441 |
| recX-2 | ruvC | MXAN_6708 | MXAN_4973 | Conserved hypothetical protein; Modulates RecA activity; Belongs to the RecX family. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.600 |
| recX-2 | topA | MXAN_6708 | MXAN_3002 | Conserved hypothetical protein; Modulates RecA activity; Belongs to the RecX family. | Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...] | 0.441 |
| rnc | ruvC | MXAN_3762 | MXAN_4973 | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.655 |
| rnc | topA | MXAN_3762 | MXAN_3002 | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...] | 0.495 |
| ruvA | MXAN_4974 | MXAN_4972 | MXAN_4974 | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Conserved hypothetical protein TIGR01033; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | 0.878 |
| ruvA | recX | MXAN_4972 | MXAN_1997 | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.436 |
| ruvA | ruvB | MXAN_4972 | MXAN_4969 | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.998 |
| ruvA | ruvC | MXAN_4972 | MXAN_4973 | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.995 |
| ruvA | topA | MXAN_4972 | MXAN_3002 | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...] | 0.537 |
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