tdk protein (Myxococcus xanthus) - STRING interaction network

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Score

tdk

Thymidine kinase; Identified by match to protein family HMM PF00265. (199 aa)

Predicted Functional Partners:

dut

0.968

thyA

0.967

MXAN_4044

0.939

deoD

0.933

tmk-2

0.932

tmk

0.932

cdd

0.932

pdp

0.930

MXAN_5325

0.929

MXAN_2470

0.928

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_2470	MXAN_4044	MXAN_2470	MXAN_4044	Identified by match to protein family HMM PF02872.	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	0.902
MXAN_2470	MXAN_5325	MXAN_2470	MXAN_5325	Identified by match to protein family HMM PF02872.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.929
MXAN_2470	cdd	MXAN_2470	MXAN_5706	Identified by match to protein family HMM PF02872.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.916
MXAN_2470	deoD	MXAN_2470	MXAN_2306	Identified by match to protein family HMM PF02872.	Purine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107.	0.901
MXAN_2470	dut	MXAN_2470	MXAN_2076	Identified by match to protein family HMM PF02872.	dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.900
MXAN_2470	pdp	MXAN_2470	MXAN_5710	Identified by match to protein family HMM PF02872.	Pyrimidine-nucleoside phosphorylase; Identified by similarity to SP:P77836; match to protein family HMM PF00591; match to protein family HMM PF02885; match to protein family HMM PF07831; match to protein family HMM TIGR02644.	0.903
MXAN_2470	tdk	MXAN_2470	MXAN_5072	Identified by match to protein family HMM PF02872.	Thymidine kinase; Identified by match to protein family HMM PF00265.	0.928
MXAN_2470	thyA	MXAN_2470	MXAN_5942	Identified by match to protein family HMM PF02872.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.903
MXAN_2470	tmk	MXAN_2470	MXAN_3412	Identified by match to protein family HMM PF02872.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.914
MXAN_2470	tmk-2	MXAN_2470	MXAN_2582	Identified by match to protein family HMM PF02872.	Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.912
MXAN_4044	MXAN_2470	MXAN_4044	MXAN_2470	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	Identified by match to protein family HMM PF02872.	0.902
MXAN_4044	MXAN_5325	MXAN_4044	MXAN_5325	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.902
MXAN_4044	dut	MXAN_4044	MXAN_2076	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.	0.948
MXAN_4044	tdk	MXAN_4044	MXAN_5072	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	Thymidine kinase; Identified by match to protein family HMM PF00265.	0.939
MXAN_4044	thyA	MXAN_4044	MXAN_5942	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.943
MXAN_4044	tmk	MXAN_4044	MXAN_3412	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.923
MXAN_4044	tmk-2	MXAN_4044	MXAN_2582	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.923
MXAN_5325	MXAN_2470	MXAN_5325	MXAN_2470	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Identified by match to protein family HMM PF02872.	0.929
MXAN_5325	MXAN_4044	MXAN_5325	MXAN_4044	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Cytidine and deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383.	0.902
MXAN_5325	cdd	MXAN_5325	MXAN_5706	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.905