MXAN_5134 protein (Myxococcus xanthus) - STRING interaction network

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MXAN_5134

mutS domain protein; Identified by match to protein family HMM PF00488; Belongs to the DNA mismatch repair MutS family. (644 aa)

Predicted Functional Partners:

mutL

0.963

topB

0.934

dnaN

0.923

MXAN_3601

0.919

polA

0.842

MXAN_0335

0.755

topA

0.699

MXAN_5133

0.568

MXAN_1620

0.511

MXAN_0144

0.475

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_0144	MXAN_5134	MXAN_0144	MXAN_5134	Hypothetical protein; Identified by Glimmer2; putative.	mutS domain protein; Identified by match to protein family HMM PF00488; Belongs to the DNA mismatch repair MutS family.	0.475
MXAN_0144	polA	MXAN_0144	MXAN_3109	Hypothetical protein; Identified by Glimmer2; putative.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.445
MXAN_0144	topA	MXAN_0144	MXAN_3002	Hypothetical protein; Identified by Glimmer2; putative.	Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...]	0.619
MXAN_0144	topB	MXAN_0144	MXAN_0535	Hypothetical protein; Identified by Glimmer2; putative.	DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF01131; match to protein family HMM PF01751; match to protein family HMM TIGR00614; match to protein family HMM TIGR01056.	0.495
MXAN_0335	MXAN_1620	MXAN_0335	MXAN_1620	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	0.913
MXAN_0335	MXAN_3601	MXAN_0335	MXAN_3601	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	ATPase; Identified by match to protein family HMM PF02518.	0.735
MXAN_0335	MXAN_5134	MXAN_0335	MXAN_5134	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	mutS domain protein; Identified by match to protein family HMM PF00488; Belongs to the DNA mismatch repair MutS family.	0.755
MXAN_0335	dnaN	MXAN_0335	MXAN_0236	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.954
MXAN_0335	mutL	MXAN_0335	MXAN_4026	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.735
MXAN_0335	polA	MXAN_0335	MXAN_3109	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.488
MXAN_0335	topA	MXAN_0335	MXAN_3002	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...]	0.623
MXAN_0335	topB	MXAN_0335	MXAN_0535	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF01131; match to protein family HMM PF01751; match to protein family HMM TIGR00614; match to protein family HMM TIGR01056.	0.970
MXAN_1620	MXAN_0335	MXAN_1620	MXAN_0335	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	Identified by match to protein family HMM PF01367; match to protein family HMM PF02739.	0.913
MXAN_1620	MXAN_3601	MXAN_1620	MXAN_3601	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	ATPase; Identified by match to protein family HMM PF02518.	0.440
MXAN_1620	MXAN_5134	MXAN_1620	MXAN_5134	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	mutS domain protein; Identified by match to protein family HMM PF00488; Belongs to the DNA mismatch repair MutS family.	0.511
MXAN_1620	dnaN	MXAN_1620	MXAN_0236	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.991
MXAN_1620	mutL	MXAN_1620	MXAN_4026	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.440
MXAN_1620	polA	MXAN_1620	MXAN_3109	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.939
MXAN_1620	topA	MXAN_1620	MXAN_3002	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	Putative DNA protecting protein DprA/DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the un [...]	0.437
MXAN_1620	topB	MXAN_1620	MXAN_0535	Putative DNA polymerase II; Identified by match to protein family HMM PF00136; match to protein family HMM PF03104.	DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF01131; match to protein family HMM PF01751; match to protein family HMM TIGR00614; match to protein family HMM TIGR01056.	0.935