MXAN_5361 protein (Myxococcus xanthus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

MXAN_5361

Putative 5`-nucleotidase; Identified by similarity to GB:AAM97494.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. (536 aa)

Predicted Functional Partners:

MXAN_4364

0.975

MXAN_6266

0.931

MXAN_2661

0.930

udk

0.930

MXAN_2236

0.929

MXAN_2470

0.929

MXAN_5325

0.928

tdk

0.920

MXAN_1438

0.914

tmk-2

0.912

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_1438	MXAN_2236	MXAN_1438	MXAN_2236	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.914
MXAN_1438	MXAN_2470	MXAN_1438	MXAN_2470	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	Identified by match to protein family HMM PF02872.	0.914
MXAN_1438	MXAN_2661	MXAN_1438	MXAN_2661	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872.	0.914
MXAN_1438	MXAN_4364	MXAN_1438	MXAN_4364	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	Identified by match to protein family HMM PF02872.	0.914
MXAN_1438	MXAN_5325	MXAN_1438	MXAN_5325	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.914
MXAN_1438	MXAN_5361	MXAN_1438	MXAN_5361	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	Putative 5`-nucleotidase; Identified by similarity to GB:AAM97494.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.914
MXAN_2236	MXAN_1438	MXAN_2236	MXAN_1438	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	0.914
MXAN_2236	MXAN_2470	MXAN_2236	MXAN_2470	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Identified by match to protein family HMM PF02872.	0.976
MXAN_2236	MXAN_2661	MXAN_2236	MXAN_2661	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872.	0.930
MXAN_2236	MXAN_4364	MXAN_2236	MXAN_4364	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Identified by match to protein family HMM PF02872.	0.969
MXAN_2236	MXAN_5325	MXAN_2236	MXAN_5325	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.929
MXAN_2236	MXAN_5361	MXAN_2236	MXAN_5361	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Putative 5`-nucleotidase; Identified by similarity to GB:AAM97494.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.929
MXAN_2236	MXAN_6266	MXAN_2236	MXAN_6266	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Putative 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Identified by similarity to SP:P08331; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.980
MXAN_2236	tdk	MXAN_2236	MXAN_5072	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Thymidine kinase; Identified by match to protein family HMM PF00265.	0.914
MXAN_2236	tmk-2	MXAN_2236	MXAN_2582	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.912
MXAN_2236	udk	MXAN_2236	MXAN_4159	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	Uridine kinase; Identified by similarity to SP:P31218; match to protein family HMM PF00485; match to protein family HMM TIGR00235.	0.917
MXAN_2470	MXAN_1438	MXAN_2470	MXAN_1438	Identified by match to protein family HMM PF02872.	Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; Belongs to the CinA family.	0.914
MXAN_2470	MXAN_2236	MXAN_2470	MXAN_2236	Identified by match to protein family HMM PF02872.	Putative 5'-nucleotidase; Identified by similarity to GB:AAD33949.1; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family.	0.976
MXAN_2470	MXAN_2661	MXAN_2470	MXAN_2661	Identified by match to protein family HMM PF02872.	Identified by match to protein family HMM PF00149; match to protein family HMM PF02872.	0.976
MXAN_2470	MXAN_4364	MXAN_2470	MXAN_4364	Identified by match to protein family HMM PF02872.	Identified by match to protein family HMM PF02872.	0.974

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.739

expected number of edges:

20

PPI enrichment p-value:

0.0104

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

6 of 12

1.94

3.13

7.92e-08

GO:0006091

Generation of precursor metabolites and energy

7 of 27

1.66

2.62

7.92e-08

GO:0006006

Glucose metabolic process

4 of 8

1.94

2.31

1.28e-05

GO:0006094

Gluconeogenesis

3 of 5

2.02

1.82

0.00024

GO:0016310

Phosphorylation

8 of 109

1.11

1.32

1.07e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000015

Phosphopyruvate hydratase complex

2 of 2

2.25

0.95

0.0177

GO:0009986

Cell surface

2 of 3

2.07

0.93

0.0177

GO:0009274

Peptidoglycan-based cell wall

2 of 5

1.85

0.87

0.0204

GO:0005576

Extracellular region

2 of 13

1.43

0.63

0.0498

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25152889

(2014) Metabolic Engineering of Escherichia coli for Production of Mixed-Acid Fermentation End Products.

5 of 12

1.87

2.43

3.85e-06

PMID:32432104

(2020) Recent Advances in Metabolically Engineered Microorganisms for the Production of Aromatic Chemicals Derived From Aromatic Amino Acids.

3 of 8

1.82

1.22

0.0035

PMID:35638860

(2022) Metatranscriptomics Unravel Composition, Drivers, and Functions of the Active Microorganisms in Light-Flavor Liquor Fermentation.

3 of 11

1.68

1.11

0.0051

PMID:38298832

(2024) Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics.

2 of 2

2.25

1.0

0.0139

PMID:37969339

(2023) Complete genome sequence of Pediococcus acidilactici CACC 537 isolated from canine.

2 of 3

2.07

0.92

0.0185

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2073

Glycolysis, and Aldehyde-lyase activity

8 of 15

1.97

4.48

7.08e-12

CL:2067

Carbon metabolism, and Alcohol dehydrogenase-like, N-terminal

9 of 63

1.4

2.34

6.10e-10

CL:2075

Glycolysis, and Aldehyde-lyase activity

4 of 8

1.94

2.32

1.20e-05

CL:982

Glycerate kinase, and Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

2 of 5

1.85

0.84

0.0245

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

paci00260

Glycine, serine and threonine metabolism

4 of 7

2.0

2.68

1.97e-06

paci00680

Methane metabolism

5 of 15

1.77

2.64

3.74e-07

paci00010

Glycolysis / Gluconeogenesis

7 of 35

1.55

2.57

8.86e-09

paci01200

Carbon metabolism

9 of 59

1.43

2.53

6.95e-11

paci01230

Biosynthesis of amino acids

7 of 37

1.52

2.5

1.00e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

6 of 9

2.07

3.77

4.78e-09

KW-0312

Gluconeogenesis

3 of 4

2.12

1.76

0.00037

KW-0964

Secreted

2 of 3

2.07

0.97

0.0152

KW-0456

Lyase

3 of 25

1.32

0.78

0.0161

KW-0670

Pyruvate

2 of 9

1.59

0.66

0.0491

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01193

Enolase, N-terminal domain

2 of 2

2.25

0.96

0.0166

SM01192

Enolase, C-terminal TIM barrel domain

2 of 2

2.25

0.96

0.0166

SM00855

Phosphoglycerate mutase family

2 of 6

1.77

0.82

0.0256

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