MXAN_6669 protein (Myxococcus xanthus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

MXAN_6669

Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069. (356 aa)

Predicted Functional Partners:

MXAN_4398

0.811

pph1

0.802

MXAN_5349

0.800

MXAN_1412

0.794

MXAN_5591

0.434

MXAN_1361

0.423

MXAN_2464

0.419

MXAN_4649

0.415

MXAN_2001

0.411

Your Current Organism:

Myxococcus xanthus

NCBI taxonomy Id: 246197
Other names: M. xanthus DK 1622, Myxococcus xanthus DK 1622

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXAN_1361	MXAN_5591	MXAN_1361	MXAN_5591	FHA domain protein; Identified by match to protein family HMM PF00498.	FHA domain/tetratricopeptide repeat protein; Identified by match to protein family HMM PF00498; match to protein family HMM PF07719.	0.772
MXAN_1361	MXAN_6669	MXAN_1361	MXAN_6669	FHA domain protein; Identified by match to protein family HMM PF00498.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.423
MXAN_1412	MXAN_6669	MXAN_1412	MXAN_6669	Putative serine/threonine protein phosphatase; Identified by similarity to GB:AAF81068.1; match to protein family HMM PF00481.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.794
MXAN_2001	MXAN_4398	MXAN_2001	MXAN_4398	FHA domain protein; Identified by match to protein family HMM PF00498.	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	0.618
MXAN_2001	MXAN_6669	MXAN_2001	MXAN_6669	FHA domain protein; Identified by match to protein family HMM PF00498.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.411
MXAN_2001	pph1	MXAN_2001	MXAN_2044	FHA domain protein; Identified by match to protein family HMM PF00498.	Protein phosphatase 1; Identified by similarity to GB:AAF81068.1; match to protein family HMM PF00481.	0.467
MXAN_2464	MXAN_6669	MXAN_2464	MXAN_6669	FHA domain protein; Identified by match to protein family HMM PF00498.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.419
MXAN_4398	MXAN_2001	MXAN_4398	MXAN_2001	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	FHA domain protein; Identified by match to protein family HMM PF00498.	0.618
MXAN_4398	MXAN_4649	MXAN_4398	MXAN_4649	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	FHA domain protein; Identified by match to protein family HMM PF00498.	0.419
MXAN_4398	MXAN_5591	MXAN_4398	MXAN_5591	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	FHA domain/tetratricopeptide repeat protein; Identified by match to protein family HMM PF00498; match to protein family HMM PF07719.	0.457
MXAN_4398	MXAN_6669	MXAN_4398	MXAN_6669	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.811
MXAN_4649	MXAN_4398	MXAN_4649	MXAN_4398	FHA domain protein; Identified by match to protein family HMM PF00498.	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	0.419
MXAN_4649	MXAN_6669	MXAN_4649	MXAN_6669	FHA domain protein; Identified by match to protein family HMM PF00498.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.415
MXAN_5349	MXAN_6669	MXAN_5349	MXAN_6669	Serine/threonine protein phosphatase, 2C family; Identified by similarity to GB:AAF81068.1; match to protein family HMM PF00481.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.800
MXAN_5591	MXAN_1361	MXAN_5591	MXAN_1361	FHA domain/tetratricopeptide repeat protein; Identified by match to protein family HMM PF00498; match to protein family HMM PF07719.	FHA domain protein; Identified by match to protein family HMM PF00498.	0.772
MXAN_5591	MXAN_4398	MXAN_5591	MXAN_4398	FHA domain/tetratricopeptide repeat protein; Identified by match to protein family HMM PF00498; match to protein family HMM PF07719.	Protein phosphatase/cyclic nucleotide-binding domain protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00481.	0.457
MXAN_5591	MXAN_6669	MXAN_5591	MXAN_6669	FHA domain/tetratricopeptide repeat protein; Identified by match to protein family HMM PF00498; match to protein family HMM PF07719.	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	0.434
MXAN_5591	pph1	MXAN_5591	MXAN_2044	FHA domain/tetratricopeptide repeat protein; Identified by match to protein family HMM PF00498; match to protein family HMM PF07719.	Protein phosphatase 1; Identified by similarity to GB:AAF81068.1; match to protein family HMM PF00481.	0.415
MXAN_6669	MXAN_1361	MXAN_6669	MXAN_1361	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	FHA domain protein; Identified by match to protein family HMM PF00498.	0.423
MXAN_6669	MXAN_1412	MXAN_6669	MXAN_1412	Putative serine/threonine protein kinase; Identified by match to protein family HMM PF00069.	Putative serine/threonine protein phosphatase; Identified by similarity to GB:AAF81068.1; match to protein family HMM PF00481.	0.794

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033184

Positive regulation of histone ubiquitination

3 of 3

3.98

3.94

8.49e-08

GO:0009788

Negative regulation of abscisic acid-activated signaling pathway

3 of 87

2.52

2.3

5.00e-05

GO:0045324

Late endosome to vacuole transport

3 of 138

2.32

2.04

0.00013

GO:0016197

Endosomal transport

3 of 227

2.1

1.73

0.00042

GO:0032940

Secretion by cell

3 of 311

1.96

1.55

0.00082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004197

Cysteine-type endopeptidase activity

6 of 438

2.12

3.78

6.84e-09

GO:0043621

Protein self-association

3 of 640

1.65

0.88

0.0166

GO:0140096

Catalytic activity, acting on a protein

10 of 12949

0.87

7.24e-06

GO:0004842

Ubiquitin-protein transferase activity

4 of 2092

1.26

0.74

0.0182

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005764

Lysosome

6 of 339

2.23

4.4

5.03e-10

GO:0005615

Extracellular space

6 of 730

1.89

3.28

1.59e-08

GO:0005769

Early endosome

3 of 105

2.44

2.38

3.19e-05

GO:0005802

trans-Golgi network

3 of 598

1.68

1.18

0.0034

GO:0000325

Plant-type vacuole

3 of 1274

1.35

0.75

0.0211

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:155551

Granulin, and YggU-like superfamily

7 of 20

3.52

10.3

1.61e-19

CL:155556

Granulin, and YggU-like superfamily

6 of 15

3.58

9.17

2.17e-17

CL:155561

Granulin, and YggU-like superfamily

4 of 10

3.58

5.63

6.67e-11

CL:29896

Mind bomb, SH3 repeat domain, and Extension to Ser/Thr-type protein kinases

3 of 11

3.42

3.61

2.99e-07

CL:155566

YggU-like superfamily, and Granulin

2 of 5

3.58

2.2

0.00011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04145

Phagosome

6 of 495

2.06

4.04

8.11e-10

map04144

Endocytosis

3 of 1052

1.44

0.87

0.0123

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6798695

Neutrophil degranulation

6 of 5151

1.05

0.77

0.0046

MAP-168249

Innate Immune System

6 of 6470

0.95

0.66

0.0078

MAP-168256

Immune System

7 of 10100

0.82

0.58

0.0078

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005769

Early endosome

3 of 114

2.4

1.99

0.00018

GOCC:0110165

Cellular anatomical entity

10 of 8339

1.06

1.29

1.70e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0788

Thiol protease

5 of 199

2.38

4.19

4.28e-09

KW-0040

ANK repeat

3 of 502

1.76

1.31

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00069

Protein kinase domain

3 of 474

1.78

0.68

0.0488

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037277

Granulin superfamily

5 of 21

3.36

6.56

1.12e-12

IPR000118

Granulin

5 of 21

3.36

6.56

1.12e-12

IPR039417

Papain-like cysteine endopeptidase

7 of 240

2.44

5.85

1.12e-12

IPR013128

Peptidase C1A

7 of 259

2.41

5.79

1.12e-12

IPR000668

Peptidase C1A, papain C-terminal

7 of 262

2.41

5.78

1.12e-12

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00277

Granulin

5 of 21

3.36

7.13

9.56e-14

SM00645

Papain family cysteine protease

7 of 247

2.43

6.28

9.56e-14

SM00848

Cathepsin propeptide inhibitor domain (I29)

5 of 247

2.29

3.98

7.64e-09

SM00248

Ankyrin repeats

3 of 525

1.74

1.21

0.0033

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