| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUS_4620 | queD | CUS_4620 | CUS_5136 | Hypothetical protein. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.473 |
| CUS_5884 | queD | CUS_5884 | CUS_5136 | Identified by match to protein family HMM PF00149. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.450 |
| CUS_5993 | folE | CUS_5993 | CUS_5138 | Dinuclear metal center protein, YbgI family; Identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486. | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | 0.780 |
| CUS_5993 | queD | CUS_5993 | CUS_5136 | Dinuclear metal center protein, YbgI family; Identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.724 |
| cysS | queD | CUS_6940 | CUS_5136 | cysteine--tRNA ligase; Identified by match to protein family HMM PF01406; match to protein family HMM PF09190; match to protein family HMM PF09334; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.511 |
| folE | CUS_5993 | CUS_5138 | CUS_5993 | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | Dinuclear metal center protein, YbgI family; Identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486. | 0.780 |
| folE | queC | CUS_5138 | CUS_5139 | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | 0.871 |
| folE | queD | CUS_5138 | CUS_5136 | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.998 |
| folE | queE | CUS_5138 | CUS_5137 | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | Putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.960 |
| folE | queF | CUS_5138 | CUS_5140 | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.872 |
| nrdG | queC | CUS_5375 | CUS_5139 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | 0.739 |
| nrdG | queD | CUS_5375 | CUS_5136 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.776 |
| nrdG | queF | CUS_5375 | CUS_5140 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.677 |
| nrdG-2 | queC | CUS_7761 | CUS_5139 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | 0.739 |
| nrdG-2 | queD | CUS_7761 | CUS_5136 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.776 |
| nrdG-2 | queF | CUS_7761 | CUS_5140 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | preQ(1) synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.677 |
| queC | folE | CUS_5139 | CUS_5138 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | 0.871 |
| queC | nrdG | CUS_5139 | CUS_5375 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.739 |
| queC | nrdG-2 | CUS_5139 | CUS_7761 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.739 |
| queC | queD | CUS_5139 | CUS_5136 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). | Queuosine biosynthesis protein QueD; Identified by match to protein family HMM PF01242; match to protein family HMM TIGR03367. | 0.995 |