CUS_5152 protein (Ruminococcus albus 8) - STRING interaction network

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CUS_5152

Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (455 aa)

Predicted Functional Partners:

trpA

0.994

trpC

0.873

ilvA

0.864

trpB

0.843

glyA

0.836

CUS_7237

0.829

thrH

0.728

CUS_6930

0.728

CUS_5337

0.640

CUS_5848

0.577

Your Current Organism:

Ruminococcus albus 8

NCBI taxonomy Id: 246199
Other names: R. albus 8, Ruminococcus albus str. 8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUS_5152	CUS_5337	CUS_5152	CUS_5337	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	0.640
CUS_5152	CUS_5848	CUS_5152	CUS_5848	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Putative glycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.577
CUS_5152	CUS_6930	CUS_5152	CUS_6930	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Identified by match to protein family HMM PF00300.	0.728
CUS_5152	CUS_7237	CUS_5152	CUS_7237	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	CDP-alcohol phosphatidyltransferase; Identified by match to protein family HMM PF01066.	0.829
CUS_5152	glyA	CUS_5152	CUS_6839	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.836
CUS_5152	ilvA	CUS_5152	CUS_6532	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.864
CUS_5152	thrH	CUS_5152	CUS_6866	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137.	0.728
CUS_5152	trpA	CUS_5152	CUS_7843	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.994
CUS_5152	trpB	CUS_5152	CUS_7844	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.843
CUS_5152	trpC	CUS_5152	CUS_7845	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	Indole-3-glycerol phosphate synthase; Identified by match to protein family HMM PF00218; Belongs to the TrpC family.	0.873
CUS_5337	CUS_5152	CUS_5337	CUS_5152	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.640
CUS_5337	CUS_5848	CUS_5337	CUS_5848	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Putative glycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.781
CUS_5337	CUS_6930	CUS_5337	CUS_6930	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Identified by match to protein family HMM PF00300.	0.739
CUS_5337	CUS_7237	CUS_5337	CUS_7237	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	CDP-alcohol phosphatidyltransferase; Identified by match to protein family HMM PF01066.	0.728
CUS_5337	glyA	CUS_5337	CUS_6839	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.814
CUS_5337	ilvA	CUS_5337	CUS_6532	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.883
CUS_5337	thrH	CUS_5337	CUS_6866	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137.	0.638
CUS_5337	trpA	CUS_5337	CUS_7843	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.755
CUS_5337	trpB	CUS_5337	CUS_7844	Aminotransferase, class V; Identified by match to protein family HMM PF00266.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.755
CUS_5848	CUS_5152	CUS_5848	CUS_5152	Putative glycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.577