| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUS_6231 | CUS_7361 | CUS_6231 | CUS_7361 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | 0.966 |
| CUS_6231 | aroA | CUS_6231 | CUS_5300 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.973 |
| CUS_6231 | aroB | CUS_6231 | CUS_5299 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.961 |
| CUS_6231 | aroC | CUS_6231 | CUS_5307 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.970 |
| CUS_6231 | aroK | CUS_6231 | CUS_6350 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.989 |
| CUS_6231 | aroQ | CUS_6231 | CUS_7129 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | 0.879 |
| CUS_6231 | nifJ | CUS_6231 | CUS_6517 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. | 0.906 |
| CUS_6231 | recA | CUS_6231 | CUS_6932 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.801 |
| CUS_6231 | trpD | CUS_6231 | CUS_7846 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.930 |
| CUS_6231 | trpE | CUS_6231 | CUS_7847 | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.842 |
| CUS_7361 | CUS_6231 | CUS_7361 | CUS_6231 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | 0.966 |
| CUS_7361 | aroA | CUS_7361 | CUS_5300 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.994 |
| CUS_7361 | aroB | CUS_7361 | CUS_5299 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.971 |
| CUS_7361 | aroC | CUS_7361 | CUS_5307 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.991 |
| CUS_7361 | aroK | CUS_7361 | CUS_6350 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.976 |
| CUS_7361 | aroQ | CUS_7361 | CUS_7129 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | 0.663 |
| CUS_7361 | nifJ | CUS_7361 | CUS_6517 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. | 0.889 |
| CUS_7361 | trpD | CUS_7361 | CUS_7846 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.971 |
| CUS_7361 | trpE | CUS_7361 | CUS_7847 | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01817. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.962 |
| aroA | CUS_6231 | CUS_5300 | CUS_6231 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative shikimate dehydrogenase; Identified by match to protein family HMM PF08501. | 0.973 |