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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prs_2Ribose-phosphate diphosphokinase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (384 aa)    
Predicted Functional Partners:
pgcA
Phosphoglucomutase; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879.
  
 0.930
CUS_5961
Putative amidophosphoribosyltransferase; Identified by match to protein family HMM PF00156; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.923
rpiB
Ribose-5-phosphate isomerase B; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.
    
 0.919
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
  
 
 0.918
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.913
CUS_5794
Transketolase, thiamine pyrophosphate binding domain protein; Identified by match to protein family HMM PF00456.
    
 0.911
CUS_5795
Transketolase, pyridine binding domain protein; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780.
    
  0.910
hisZ
ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
    
 0.909
CUS_7330
Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293.
    
  0.909
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 0.885
Your Current Organism:
Ruminococcus albus 8
NCBI taxonomy Id: 246199
Other names: R. albus 8, Ruminococcus albus str. 8
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