thiF protein (Ruminococcus albus 8) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

thiF

Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM TIGR02354. (211 aa)

Predicted Functional Partners:

thiG

0.983

thiS

0.974

thiH

0.922

CUS_5657

0.839

thiE

0.746

thiC

0.581

thiD

0.498

Your Current Organism:

Ruminococcus albus 8

NCBI taxonomy Id: 246199
Other names: R. albus 8, Ruminococcus albus str. 8

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUS_5657	thiC	CUS_5657	CUS_6958	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.823
CUS_5657	thiD	CUS_5657	CUS_6957	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	0.814
CUS_5657	thiE	CUS_5657	CUS_6956	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.833
CUS_5657	thiF	CUS_5657	CUS_6953	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM TIGR02354.	0.839
CUS_5657	thiG	CUS_5657	CUS_6954	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.995
CUS_5657	thiH	CUS_5657	CUS_6955	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Thiazole biosynthesis protein ThiH; Identified by match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR02351.	0.688
CUS_5657	thiS	CUS_5657	CUS_6952	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.	0.993
thiC	CUS_5657	CUS_6958	CUS_5657	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	0.823
thiC	thiD	CUS_6958	CUS_6957	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	0.998
thiC	thiE	CUS_6958	CUS_6956	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.971
thiC	thiF	CUS_6958	CUS_6953	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM TIGR02354.	0.581
thiC	thiG	CUS_6958	CUS_6954	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.974
thiC	thiH	CUS_6958	CUS_6955	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Thiazole biosynthesis protein ThiH; Identified by match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR02351.	0.956
thiC	thiS	CUS_6958	CUS_6952	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.	0.929
thiD	CUS_5657	CUS_6957	CUS_5657	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	Identified by match to protein family HMM PF00581; match to protein family HMM PF00899; match to protein family HMM PF05237; overlaps another CDS with the same product name.	0.814
thiD	thiC	CUS_6957	CUS_6958	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.998
thiD	thiE	CUS_6957	CUS_6956	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.999
thiD	thiF	CUS_6957	CUS_6953	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM TIGR02354.	0.498
thiD	thiG	CUS_6957	CUS_6954	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.890
thiD	thiH	CUS_6957	CUS_6955	Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543; match to protein family HMM TIGR00097.	Thiazole biosynthesis protein ThiH; Identified by match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR02351.	0.675