STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (194 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.984
CUS_4768
Hypothetical protein.
  
 
 0.804
CUS_7702
Identified by match to protein family HMM PF00817.
  
 
 0.804
CUS_7724
Identified by match to protein family HMM PF00817.
  
 
 0.804
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
     
 0.773
CUS_7404
Hypothetical protein; Identified by glimmer; putative.
       0.658
recN
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.644
CUS_6294
Peptidase M15; Identified by match to protein family HMM PF01453; match to protein family HMM PF08291.
      
 0.613
CUS_7400
Stage V sporulation protein G; Identified by match to protein family HMM PF04026; Belongs to the SpoVG family.
     
 0.562
CUS_7401
Hypothetical protein; Identified by glimmer; putative.
       0.549
Your Current Organism:
Ruminococcus albus 8
NCBI taxonomy Id: 246199
Other names: R. albus 8, Ruminococcus albus str. 8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.