Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cotJCcotJC protein; Identified by match to protein family HMM PF05067. (199 aa)    
Predicted Functional Partners:
CUS_7497
Hypothetical protein.
 
  
 0.987
spoIVA
Stage IV sporulation protein A; Identified by match to protein family HMM PF09547; match to protein family HMM TIGR02836.
  
  
 0.884
CUS_7496
Hypothetical protein.
 
    0.848
CUS_7495
Hypothetical protein; Identified by glimmer; putative.
       0.773
spoVAC
Stage V sporulation protein AC; Identified by match to protein family HMM PF03862; match to protein family HMM TIGR02838.
  
    0.684
gpr
Putative GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
    0.664
spoVAD
Stage V sporulation protein AD; Identified by match to protein family HMM PF07451.
  
     0.635
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.618
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.618
spoVAE
Stage V sporulation protein AE; Identified by match to protein family HMM PF03862; match to protein family HMM TIGR02839.
  
     0.598
Your Current Organism:
Ruminococcus albus 8
NCBI taxonomy Id: 246199
Other names: R. albus 8, Ruminococcus albus str. 8
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.