Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hydEIron-only hydrogenase maturation rSAM protein HydE; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR03956. (347 aa)    
Predicted Functional Partners:
hydF
Hydrogenase maturation GTPase HydF; Identified by match to protein family HMM PF01926; match to protein family HMM PF08477; match to protein family HMM TIGR00231; match to protein family HMM TIGR03918.
   
 0.991
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.935
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
  
 
 0.909
CUS_7924
Putative iron-only hydrogenase system regulator; Identified by match to protein family HMM TIGR03959.
 
    0.860
CUS_7931
Conserved domain protein.
 
     0.813
CUS_4661
Ferredoxin hydrogenase; Identified by match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM PF02256; match to protein family HMM PF02906; match to protein family HMM TIGR02512.
 
  
 0.800
CUS_7930
Putative nitrogenase iron protein; Identified by match to protein family HMM PF00142; Belongs to the NifH/BchL/ChlL family.
       0.780
CUS_7928
Hypothetical protein; Identified by glimmer; putative.
       0.773
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
  0.761
bioA
Adenosylmethionine-8-amino-7-oxononanoate transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.758
Your Current Organism:
Ruminococcus albus 8
NCBI taxonomy Id: 246199
Other names: R. albus 8, Ruminococcus albus str. 8
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