| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUS_8089 | CUS_8091 | CUS_8089 | CUS_8091 | Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | Conserved domain protein. | 0.521 |
| CUS_8089 | folC-2 | CUS_8089 | CUS_8090 | Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.650 |
| CUS_8091 | CUS_8089 | CUS_8091 | CUS_8089 | Conserved domain protein. | Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | 0.521 |
| CUS_8091 | folC-2 | CUS_8091 | CUS_8090 | Conserved domain protein. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.630 |
| cmk | folC | CUS_7773 | CUS_5042 | Cytidylate kinase; Identified by match to protein family HMM PF01553; match to protein family HMM PF02224; match to protein family HMM TIGR00017. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.582 |
| cmk | folC-2 | CUS_7773 | CUS_8090 | Cytidylate kinase; Identified by match to protein family HMM PF01553; match to protein family HMM PF02224; match to protein family HMM TIGR00017. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.570 |
| cmk | glyA | CUS_7773 | CUS_6839 | Cytidylate kinase; Identified by match to protein family HMM PF01553; match to protein family HMM PF02224; match to protein family HMM TIGR00017. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.467 |
| cmk | guaA | CUS_7773 | CUS_6755 | Cytidylate kinase; Identified by match to protein family HMM PF01553; match to protein family HMM PF02224; match to protein family HMM TIGR00017. | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. | 0.736 |
| cmk | trpD | CUS_7773 | CUS_7846 | Cytidylate kinase; Identified by match to protein family HMM PF01553; match to protein family HMM PF02224; match to protein family HMM TIGR00017. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.747 |
| fhs | folC | CUS_6200 | CUS_5042 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.574 |
| fhs | folC-2 | CUS_6200 | CUS_8090 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.574 |
| fhs | glyA | CUS_6200 | CUS_6839 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
| fhs | guaA | CUS_6200 | CUS_6755 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. | 0.744 |
| folC | cmk | CUS_5042 | CUS_7773 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Cytidylate kinase; Identified by match to protein family HMM PF01553; match to protein family HMM PF02224; match to protein family HMM TIGR00017. | 0.582 |
| folC | fhs | CUS_5042 | CUS_6200 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.574 |
| folC | folC-2 | CUS_5042 | CUS_8090 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.675 |
| folC | folE | CUS_5042 | CUS_5138 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Putative GTP cyclohydrolase I; Identified by match to protein family HMM PF01227. | 0.816 |
| folC | glyA | CUS_5042 | CUS_6839 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.643 |
| folC | guaA | CUS_5042 | CUS_6755 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. | 0.529 |
| folC | ribD | CUS_5042 | CUS_5651 | Bifunctional protein FolC; Identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.466 |
