| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO0046 | SPO0049 | SPO0046 | SPO0049 | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | 0.921 |
| SPO0046 | SPO0050 | SPO0046 | SPO0050 | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | 0.858 |
| SPO0046 | SPO0051 | SPO0046 | SPO0051 | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | TENA/THI-4 family protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | 0.824 |
| SPO0046 | thiD | SPO0046 | SPO0045 | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | Phosphomethylpyrimidine kinase; Identified by similarity to SP:P76422; match to protein family HMM TIGR00097. | 0.891 |
| SPO0046 | thiE | SPO0046 | SPO0048 | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). | 0.964 |
| SPO0046 | thiG | SPO0046 | SPO0047 | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.996 |
| SPO0046 | thiS | SPO0046 | SPO0046a | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683. | 0.969 |
| SPO0049 | SPO0046 | SPO0049 | SPO0046 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | 0.921 |
| SPO0049 | SPO0050 | SPO0049 | SPO0050 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | 0.790 |
| SPO0049 | SPO0051 | SPO0049 | SPO0051 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | TENA/THI-4 family protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | 0.839 |
| SPO0049 | SPO2056 | SPO0049 | SPO2056 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594. | 0.540 |
| SPO0049 | thiD | SPO0049 | SPO0045 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | Phosphomethylpyrimidine kinase; Identified by similarity to SP:P76422; match to protein family HMM TIGR00097. | 0.941 |
| SPO0049 | thiE | SPO0049 | SPO0048 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). | 0.984 |
| SPO0049 | thiG | SPO0049 | SPO0047 | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.991 |
| SPO0049 | thiS | SPO0049 | SPO0046a | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683. | 0.981 |
| SPO0050 | SPO0046 | SPO0050 | SPO0046 | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266. | 0.858 |
| SPO0050 | SPO0049 | SPO0050 | SPO0049 | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237. | 0.790 |
| SPO0050 | SPO0051 | SPO0050 | SPO0051 | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | TENA/THI-4 family protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | 0.945 |
| SPO0050 | thiD | SPO0050 | SPO0045 | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | Phosphomethylpyrimidine kinase; Identified by similarity to SP:P76422; match to protein family HMM TIGR00097. | 0.836 |
| SPO0050 | thiE | SPO0050 | SPO0048 | ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). | 0.863 |
