STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiSThiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683. (64 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.998
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
 
  
 0.993
SPO0049
Thiamine biosynthesis protein ThiF; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.
 
 
 0.988
thiD
Phosphomethylpyrimidine kinase; Identified by similarity to SP:P76422; match to protein family HMM TIGR00097.
 
    0.976
SPO0046
Thiamine biosynthesis oxidoreductase ThiO, putative; Identified by match to protein family HMM PF01266.
 
  
 0.973
SPO0051
TENA/THI-4 family protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.
 
    0.934
SPO0050
ABC transporter, periplasmic substrate-binding protein; Assignment based partly on membership in ABC transporter gene cluster.
 
    0.891
SPO0410
Molybdopterin biosynthesis protein MoeB, putative; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.
  
 
 0.881
SPO2748
Hypothetical protein; Identified by similarity to PIR:AG2090.
  
  
 0.845
SPO2056
Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594.
  
  
 0.836
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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