node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SPO2385 | SPO2885 | SPO2385 | SPO2885 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.924 |
SPO2385 | ilvB | SPO2385 | SPO2578 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.928 |
SPO2385 | ilvC | SPO2385 | SPO1366 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.984 |
SPO2385 | ilvN | SPO2385 | SPO2579 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.991 |
SPO2385 | leuA | SPO2385 | SPO0422 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.904 |
SPO2385 | leuB | SPO2385 | SPO0210 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.956 |
SPO2385 | leuC-2 | SPO2385 | SPO1476 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.447 |
SPO2385 | leuD-2 | SPO2385 | SPO1477 | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.527 |
SPO2885 | SPO2385 | SPO2885 | SPO2385 | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.924 |
SPO2885 | ilvB | SPO2885 | SPO2578 | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.926 |
SPO2885 | ilvC | SPO2885 | SPO1366 | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.973 |
SPO2885 | ilvN | SPO2885 | SPO2579 | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.992 |
SPO2885 | leuA | SPO2885 | SPO0422 | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.890 |
SPO2885 | leuB | SPO2885 | SPO0210 | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.950 |
ilvB | SPO2385 | SPO2578 | SPO2385 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | Benzaldehyde lyase, putative; Identified by similarity to SP:P51853; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.928 |
ilvB | SPO2885 | SPO2578 | SPO2885 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | Acetolactate synthase, catabolic, putative; Identified by similarity to SP:P27696; match to protein family HMM PF00205; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.926 |
ilvB | ilvC | SPO2578 | SPO1366 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.996 |
ilvB | ilvN | SPO2578 | SPO2579 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.999 |
ilvB | leuA | SPO2578 | SPO0422 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.946 |
ilvB | leuB | SPO2578 | SPO0210 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.983 |