| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO0132 | nadE | SPO0132 | SPO0426 | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.725 |
| SPO2469 | SPO3541 | SPO2469 | SPO3541 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | 0.909 |
| SPO2469 | cobB-2 | SPO2469 | SPO0978 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | CobB; Identified by similarity to GB:AAC78722.1; match to protein family HMM PF02146; Belongs to the sirtuin family. Class III subfamily. | 0.902 |
| SPO2469 | nadD | SPO2469 | SPO0449 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.905 |
| SPO2469 | nadE | SPO2469 | SPO0426 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.901 |
| SPO2469 | nadK | SPO2469 | SPO2939 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.902 |
| SPO2469 | pncB | SPO2469 | SPO0095 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.916 |
| SPO2469 | pntA | SPO2469 | SPO2820 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.902 |
| SPO2469 | pntB | SPO2469 | SPO2819 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | NAD(P)+ transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.903 |
| SPO2469 | sthA | SPO2469 | SPO3828 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Soluble pyridine nucleotide transhydrogenase; Identified by similarity to SP:P27306; match to protein family HMM PF00070; match to protein family HMM PF02852. | 0.908 |
| SPO3541 | SPO2469 | SPO3541 | SPO2469 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.909 |
| SPO3541 | cobB-2 | SPO3541 | SPO0978 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | CobB; Identified by similarity to GB:AAC78722.1; match to protein family HMM PF02146; Belongs to the sirtuin family. Class III subfamily. | 0.909 |
| SPO3541 | nadD | SPO3541 | SPO0449 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.906 |
| SPO3541 | nadE | SPO3541 | SPO0426 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.912 |
| SPO3541 | nadK | SPO3541 | SPO2939 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.903 |
| SPO3541 | pncB | SPO3541 | SPO0095 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.911 |
| SPO3541 | pntA | SPO3541 | SPO2820 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.900 |
| SPO3541 | pntB | SPO3541 | SPO2819 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | NAD(P)+ transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
| SPO3541 | sthA | SPO3541 | SPO3828 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Soluble pyridine nucleotide transhydrogenase; Identified by similarity to SP:P27306; match to protein family HMM PF00070; match to protein family HMM PF02852. | 0.900 |
| cobB-2 | SPO2469 | SPO0978 | SPO2469 | CobB; Identified by similarity to GB:AAC78722.1; match to protein family HMM PF02146; Belongs to the sirtuin family. Class III subfamily. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.902 |
