| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO0601 | nspC | SPO0601 | SPO0600 | Saccharopine dehydrogenase. | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | 0.995 |
| SPO0601 | speA | SPO0601 | SPO0602 | Saccharopine dehydrogenase. | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. | 0.987 |
| SPO0601 | speB-1 | SPO0601 | SPO0599 | Saccharopine dehydrogenase. | Agmatinase; Belongs to the arginase family. | 0.635 |
| SPO0791 | guaA | SPO0791 | SPO2109 | M23/M37 peptidase/aminotransferase, class III; Identified by match to protein family HMM PF00202; match to protein family HMM PF01551. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.632 |
| SPO0791 | nspC | SPO0791 | SPO0600 | M23/M37 peptidase/aminotransferase, class III; Identified by match to protein family HMM PF00202; match to protein family HMM PF01551. | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | 0.512 |
| guaA | SPO0791 | SPO2109 | SPO0791 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | M23/M37 peptidase/aminotransferase, class III; Identified by match to protein family HMM PF00202; match to protein family HMM PF01551. | 0.632 |
| guaA | guaB | SPO2109 | SPO2039 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | nspC | SPO2109 | SPO0600 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | 0.572 |
| guaA | ribB | SPO2109 | SPO1761 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.648 |
| guaA | ribD | SPO2109 | SPO1754 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.565 |
| guaB | guaA | SPO2039 | SPO2109 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | nspC | SPO2039 | SPO0600 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | 0.510 |
| guaB | pgsA | SPO2039 | SPO3635 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.562 |
| guaB | ribB | SPO2039 | SPO1761 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.837 |
| guaB | ribD | SPO2039 | SPO1754 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.565 |
| nspC | SPO0601 | SPO0600 | SPO0601 | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | Saccharopine dehydrogenase. | 0.995 |
| nspC | SPO0791 | SPO0600 | SPO0791 | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | M23/M37 peptidase/aminotransferase, class III; Identified by match to protein family HMM PF00202; match to protein family HMM PF01551. | 0.512 |
| nspC | guaA | SPO0600 | SPO2109 | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.572 |
| nspC | guaB | SPO0600 | SPO2039 | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.510 |
| nspC | pcs | SPO0600 | SPO3131 | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. | Phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.507 |