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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvH-1Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (119 aa)    
Predicted Functional Partners:
SPO1579
Identified by match to protein family HMM PF01571; Belongs to the GcvT family.
 
 0.996
SPO1648
Identified by match to protein family HMM PF01571; Belongs to the GcvT family.
 
 0.991
SPO1562
Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family.
 0.985
lpdA
2-oxoglutarate dehydrogenase, E3 component, dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM TIGR01350.
 
  
 0.979
SPO2222
Pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase, putative; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM TIGR01350.
 
  
 0.971
glyA-1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.953
glyA-3
Serine hydroxymethyltransferase; Identified by match to protein family HMM PF00464.
 
 
 0.945
SPO1567
Aminotransferase, putative.
  
 
 0.911
dmdA
DmdA; Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton, by mediating demethylation of dimethlysulfonioproprionate (DMSP) to methyl-mercaptopropionate (MMPA). The intracellular concentration of DMSP is estimated to be 70 mM. Belongs to the GcvT family. DmdA subfamily.
 
 0.911
SPO3029
Serine--glyoxylate transaminase, putative; Identified by similarity to SP:O08374; match to protein family HMM PF00266.
  
 
 0.911
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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