| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO0669 | SPO0981 | SPO0669 | SPO0981 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | 0.910 |
| SPO0669 | SPO3027 | SPO0669 | SPO3027 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | 0.826 |
| SPO0669 | hisA | SPO0669 | SPO1158 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:P26720; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.874 |
| SPO0669 | hisA2 | SPO0669 | SPO2272 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, putative; Identified by similarity to SP:P26720; match to protein family HMM PF00977. | 0.872 |
| SPO0669 | hisB | SPO0669 | SPO1163 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to SP:P18787; match to protein family HMM PF00475. | 0.959 |
| SPO0669 | hisC-2 | SPO0669 | SPO1697 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.824 |
| SPO0669 | hisE | SPO0669 | SPO1155 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | phosphoribosyl-ATP pyrophosphohydrolase; Identified by match to protein family HMM PF01503. | 0.992 |
| SPO0669 | hisF | SPO0669 | SPO1156 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.955 |
| SPO0669 | hisH | SPO0669 | SPO1162 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.957 |
| SPO0669 | hisI | SPO0669 | SPO1684 | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.962 |
| SPO0981 | SPO0669 | SPO0981 | SPO0669 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.910 |
| SPO0981 | SPO3027 | SPO0981 | SPO3027 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | 0.868 |
| SPO0981 | hisA | SPO0981 | SPO1158 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:P26720; match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.930 |
| SPO0981 | hisA2 | SPO0981 | SPO2272 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, putative; Identified by similarity to SP:P26720; match to protein family HMM PF00977. | 0.933 |
| SPO0981 | hisB | SPO0981 | SPO1163 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to SP:P18787; match to protein family HMM PF00475. | 0.995 |
| SPO0981 | hisC-2 | SPO0981 | SPO1697 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.868 |
| SPO0981 | hisE | SPO0981 | SPO1155 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | phosphoribosyl-ATP pyrophosphohydrolase; Identified by match to protein family HMM PF01503. | 0.932 |
| SPO0981 | hisF | SPO0981 | SPO1156 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.973 |
| SPO0981 | hisH | SPO0981 | SPO1162 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.962 |
| SPO0981 | hisI | SPO0981 | SPO1684 | Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.964 |
