Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPO1592Identified by match to protein family HMM PF01571; Belongs to the GcvT family. (818 aa)    
Predicted Functional Partners:
glyA-1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.937
glyA-3
Serine hydroxymethyltransferase; Identified by match to protein family HMM PF00464.
  
 0.937
folD1
folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.929
folD
folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.929
SPO1884
Identified by match to protein family HMM PF02574.
 
 
 0.927
SPO2346
Sarcosine oxidase, delta subunit family; Identified by similarity to SP:Q46336; match to protein family HMM PF04267.
 
 0.927
fhs-1
Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family.
  
 0.925
purH
Bifunctional purine biosynthesis protein PurH; Identified by similarity to SP:P26978; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355.
  
 
 0.922
SPO1562
Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family.
  
 
0.917
SPO1579
Identified by match to protein family HMM PF01571; Belongs to the GcvT family.
  
 
0.917
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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