| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO1668 | cdsA | SPO1668 | SPO1666 | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | 0.937 |
| SPO1668 | dxr | SPO1668 | SPO1667 | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.942 |
| SPO1668 | frr | SPO1668 | SPO1664 | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.907 |
| SPO1668 | lpxA | SPO1668 | SPO1673 | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.496 |
| SPO1668 | uppS | SPO1668 | SPO1665 | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.976 |
| cdsA | SPO1668 | SPO1666 | SPO1668 | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | 0.937 |
| cdsA | dxr | SPO1666 | SPO1667 | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.980 |
| cdsA | frr | SPO1666 | SPO1664 | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.928 |
| cdsA | ispDF | SPO1666 | SPO2090 | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.656 |
| cdsA | lpxA | SPO1666 | SPO1673 | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.459 |
| cdsA | uppS | SPO1666 | SPO1665 | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.985 |
| dxr | SPO1668 | SPO1667 | SPO1668 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Membrane-associated zinc metalloprotease, putative; Identified by match to protein family HMM PF00595; match to protein family HMM PF02163; match to protein family HMM TIGR00054. | 0.942 |
| dxr | cdsA | SPO1667 | SPO1666 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Phosphatidate cytidylyltransferase; Identified by similarity to SP:P06466; match to protein family HMM PF01148; Belongs to the CDS family. | 0.980 |
| dxr | dxs | SPO1667 | SPO0247 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.993 |
| dxr | frr | SPO1667 | SPO1664 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.911 |
| dxr | ispDF | SPO1667 | SPO2090 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.993 |
| dxr | ispE | SPO1667 | SPO0318 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.922 |
| dxr | ispG | SPO1667 | SPO2594 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.932 |
| dxr | ispH | SPO1667 | SPO3207 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.935 |
| dxr | lpxA | SPO1667 | SPO1673 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.778 |
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