node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SPO1562 | SPO1648 | SPO1562 | SPO1648 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | 0.922 |
SPO1562 | SPO1862 | SPO1562 | SPO1862 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | metFprotein-like protein; Identified by similarity to PIR:B97532. | 0.910 |
SPO1562 | SPO1863 | SPO1562 | SPO1863 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Pterin-binding enzyme domain protein; Identified by match to protein family HMM PF00809. | 0.906 |
SPO1562 | SPO1884 | SPO1562 | SPO1884 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Identified by match to protein family HMM PF02574. | 0.916 |
SPO1562 | folD | SPO1562 | SPO1560 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
SPO1562 | folD1 | SPO1562 | SPO1559 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.925 |
SPO1562 | glyA-1 | SPO1562 | SPO1572 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
SPO1562 | glyA-3 | SPO1562 | SPO3529 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Identified by match to protein family HMM PF00464. | 0.937 |
SPO1562 | metF | SPO1562 | SPO3016 | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to SP:P00394; match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.912 |
SPO1648 | SPO1562 | SPO1648 | SPO1562 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Glycine cleavage system T protein, putative; Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | 0.922 |
SPO1648 | SPO1862 | SPO1648 | SPO1862 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | metFprotein-like protein; Identified by similarity to PIR:B97532. | 0.925 |
SPO1648 | SPO1863 | SPO1648 | SPO1863 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Pterin-binding enzyme domain protein; Identified by match to protein family HMM PF00809. | 0.906 |
SPO1648 | SPO1884 | SPO1648 | SPO1884 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Identified by match to protein family HMM PF02574. | 0.916 |
SPO1648 | folD | SPO1648 | SPO1560 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.924 |
SPO1648 | folD1 | SPO1648 | SPO1559 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.924 |
SPO1648 | glyA-1 | SPO1648 | SPO1572 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
SPO1648 | glyA-3 | SPO1648 | SPO3529 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Identified by match to protein family HMM PF00464. | 0.936 |
SPO1648 | metF | SPO1648 | SPO3016 | Identified by match to protein family HMM PF01571; Belongs to the GcvT family. | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to SP:P00394; match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.912 |
SPO1861 | SPO1862 | SPO1861 | SPO1862 | Hypothetical protein; Identified by similarity to GB:BAB48658.1. | metFprotein-like protein; Identified by similarity to PIR:B97532. | 0.950 |
SPO1861 | SPO1863 | SPO1861 | SPO1863 | Hypothetical protein; Identified by similarity to GB:BAB48658.1. | Pterin-binding enzyme domain protein; Identified by match to protein family HMM PF00809. | 0.952 |