SPO1883 protein (Ruegeria pomeroyi) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

SPO1883

Hypothetical protein; Identified by similarity to SP:O43464. (517 aa)

Predicted Functional Partners:

SPO1333

0.900

SPO1625

0.900

SPO1882

0.681

SPO0132

0.534

SPO2208

0.503

SPO1881

0.491

SPO1424

0.487

SPO2341

0.478

glpK

0.469

ccmF

0.469

Your Current Organism:

Ruegeria pomeroyi

NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPO0132	SPO1333	SPO0132	SPO1333	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	0.534
SPO0132	SPO1424	SPO0132	SPO1424	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	0.482
SPO0132	SPO1625	SPO0132	SPO1625	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	0.592
SPO0132	SPO1882	SPO0132	SPO1882	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.	0.734
SPO0132	SPO1883	SPO0132	SPO1883	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	Hypothetical protein; Identified by similarity to SP:O43464.	0.534
SPO0132	glpK	SPO0132	SPO0104	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.431
SPO1333	SPO0132	SPO1333	SPO0132	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	0.534
SPO1333	SPO1424	SPO1333	SPO1424	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	0.487
SPO1333	SPO1625	SPO1333	SPO1625	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	0.910
SPO1333	SPO1883	SPO1333	SPO1883	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Hypothetical protein; Identified by similarity to SP:O43464.	0.900
SPO1333	glpK	SPO1333	SPO0104	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.469
SPO1424	SPO0132	SPO1424	SPO0132	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	0.482
SPO1424	SPO1333	SPO1424	SPO1333	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	0.487
SPO1424	SPO1625	SPO1424	SPO1625	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	0.497
SPO1424	SPO1883	SPO1424	SPO1883	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	Hypothetical protein; Identified by similarity to SP:O43464.	0.487
SPO1625	SPO0132	SPO1625	SPO0132	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.	0.592
SPO1625	SPO1333	SPO1625	SPO1333	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	0.910
SPO1625	SPO1424	SPO1625	SPO1424	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Glutathione-regulated potassium-efflux system protein; Identified by similarity to SP:P03819; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	0.497
SPO1625	SPO1883	SPO1625	SPO1883	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Hypothetical protein; Identified by similarity to SP:O43464.	0.900
SPO1625	glpK	SPO1625	SPO0104	Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.469

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.847

expected number of edges:

25

PPI enrichment p-value:

0.0836

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

4 of 6

1.57

1.08

0.0047

GO:0006259

DNA metabolic process

6 of 55

0.78

0.46

0.0321

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003916

DNA topoisomerase activity

4 of 6

1.57

1.19

0.0024

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 4

1.62

0.96

0.0105

GO:0140097

Catalytic activity, acting on DNA

6 of 37

0.96

0.73

0.0031

GO:0003677

DNA binding

6 of 55

0.78

0.53

0.0123

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 91

0.63

0.43

0.0150

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

4 of 12

1.27

0.91

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:403

DNA topoisomerase, type IIA-like domain superfamily, and DNA methylase, N-6 adenine-specific, conserved site

3 of 6

1.45

0.68

0.0387

CL:44

Cellular macromolecule metabolic process, and Oxidative phosphorylation

9 of 188

0.43

0.28

0.0470

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

4 of 4

1.75

1.7

0.00019

KW-0238

DNA-binding

6 of 22

1.18

1.15

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

3 of 4

1.62

0.76

0.0303

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00434

DNA Topoisomerase IV

2 of 2

1.75

0.77

0.0315

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