STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
dmdADmdA; Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton, by mediating demethylation of dimethlysulfonioproprionate (DMSP) to methyl-mercaptopropionate (MMPA). The intracellular concentration of DMSP is estimated to be 70 mM. Belongs to the GcvT family. DmdA subfamily. (364 aa)    
Predicted Functional Partners:
dmdB
3-methylmercaptopropionyl-CoA ligase; Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton. Catalyzes the ATP-dependent ligation of methylmercaptopropionate (MMPA) and CoA to yield methylmercaptopropionate-CoA (MMPA-CoA). It is also active with short-chain-fatty-acid (carboxylic acids up to six carbons in length) ; Belongs to the ATP-dependent AMP-binding enzyme family.
     
 0.957
gcvH-1
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.911
dddP
DMSP lyase; Identified by match to protein family HMM PF00557.
 
 
 0.738
acuI
NADPH-dependent acrylyl-CoA reductase; Probably catalyzes the NADPH-dependent reduction of acrylyl- CoA to propanoyl-CoA. Restores acrylate resistance when expressed in an E.coli strain K12 acuI deletion.
     
 0.714
dddD
DMSP lyase; Identified by match to protein family HMM PF02515; Belongs to the CoA-transferase III family.
   
  
 0.652
dddQ
DMSP lyase; May act as a dimethlysulfonioproprionate (DMSP) in vitro, releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethlysulfonioproprionate lyase in vivo (Probable).
      
 0.650
dddW
DMSP lyase; Able to cleave dimethlysulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which sulfur is transported from oceans to the atmosphere.
      
 0.649
dmdC
3-methylmercaptopropionyl-CoA dehydrogenase; Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton, by mediating the conversion of 3-(methylthio)propanoyl- CoA (MMPA-CoA) to 3-(methylthio)acryloyl-CoA (MTA-CoA). Belongs to the acyl-CoA dehydrogenase family.
  
 
 0.634
dmdD
Methylthioacryloyl-CoA hydratase; Involved in the assimilation of dimethylsulphoniopropionate (DMSP), an important compound in the fixation of carbon in marine phytoplankton, by catalyzing both the hydration and the hydrolysis of 3-(methylthio)acryloyl-CoA (MTA-CoA) to acetaldehyde, CO2, MeSH, and CoA.
   
  
 0.595
SPO1912
Transcriptional regulator, GntR family; Identified by match to protein family HMM PF00392.
 
     0.581
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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