SPO1995 protein (Ruegeria pomeroyi) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

SPO1995

ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664. (601 aa)

Predicted Functional Partners:

SPO1994

0.951

SPO3729

0.803

SPO1996

0.795

SPO1999

0.720

SPO1617

0.639

SPO2352

0.627

SPO2401

0.594

SPO3673

0.593

SPO0362

0.561

SPO3839

0.560

Your Current Organism:

Ruegeria pomeroyi

NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
SPO0362	SPO1994	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	0.677
SPO0362	SPO1995	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	0.561
SPO0362	SPO3729	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	0.655
SPO0362	SPO3839	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.819
SPO1617	SPO1994	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	0.749
SPO1617	SPO1995	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	0.639
SPO1617	SPO3729	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	0.724
SPO1994	SPO0362	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.677
SPO1994	SPO1617	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.749
SPO1994	SPO1995	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	0.951
SPO1994	SPO1996	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Hypothetical protein; Identified by similarity to GB:CAE79871.1.	0.615
SPO1994	SPO1999	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Collagen domain protein.	0.428
SPO1994	SPO2352	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Type I secretion target repeat protein; Identified by similarity to SP:P55127; match to protein family HMM PF00353.	0.753
SPO1994	SPO2401	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.723
SPO1994	SPO3673	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.746
SPO1994	SPO3839	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.705
SPO1995	SPO0362	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.561
SPO1995	SPO1617	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	Type I secretion target repeat protein; Identified by match to protein family HMM PF00353.	0.639
SPO1995	SPO1994	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	Type I secretion membrane fusion protein, HlyD family; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01843.	0.951
SPO1995	SPO1996	ABC transporter, ATP-binding/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.	Hypothetical protein; Identified by similarity to GB:CAE79871.1.	0.795

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16489

Trafficking of myristoylated proteins to the cilium, and ADP-ribosylation factor-like protein 2/3

5 of 5

3.18

5.67

4.06e-11

CL:27900

Neuropeptide FF receptor family, and Orexin and neuropeptides FF and QRFP bind to their respective receptors

2 of 6

2.7

1.19

0.0069

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5624138

Trafficking of myristoylated proteins to the cilium

3 of 4

3.05

2.7

1.26e-05

MAP-5620920

Cargo trafficking to the periciliary membrane

4 of 58

2.02

2.12

4.74e-05

MAP-5617833

Cilium Assembly

4 of 233

1.41

0.95

0.0068

MAP-1852241

Organelle biogenesis and maintenance

4 of 281

1.33

0.85

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

3 of 155

1.47

0.67

0.0414

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05351

GMP-PDE, delta subunit

2 of 3

3.0

1.17

0.0077

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044612

ADP-ribosylation factor-like protein 2/3

2 of 2

3.18

1.02

0.0145

IPR037036

GMP phosphodiesterase, delta subunit superfamily

2 of 3

3.0

1.02

0.0145

IPR008015

GMP phosphodiesterase, delta subunit

2 of 3

3.0

1.02

0.0145

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