| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO2025 | trmJ | SPO2025 | SPO2055 | Iron-sulfur cluster assembly transcription factor IscR, putative; Identified by similarity to GB:AAN17744.1; match to protein family HMM PF02082; match to protein family HMM TIGR00738. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.499 |
| SPO2053 | SPO2056 | SPO2053 | SPO2056 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594. | 0.537 |
| SPO2053 | ctaA | SPO2053 | SPO2054 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.869 |
| SPO2053 | trmJ | SPO2053 | SPO2055 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.749 |
| SPO2056 | SPO2053 | SPO2056 | SPO2053 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.537 |
| SPO2056 | ctaA | SPO2056 | SPO2054 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.552 |
| SPO2056 | trmJ | SPO2056 | SPO2055 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.657 |
| SPO3252 | trmJ | SPO3252 | SPO2055 | Chorismate mutase; Identified by match to protein family HMM PF01817; match to protein family HMM TIGR01795. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.477 |
| ctaA | SPO2053 | SPO2054 | SPO2053 | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.869 |
| ctaA | SPO2056 | SPO2054 | SPO2056 | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to SP:P39594. | 0.552 |
| ctaA | trmJ | SPO2054 | SPO2055 | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.749 |
| cysS | dksA | SPO2131 | SPO2511 | cysteinyl-tRNA synthetase; Identified by similarity to SP:P21888; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | dnaK suppressor protein, putative; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | 0.409 |
| cysS | trmJ | SPO2131 | SPO2055 | cysteinyl-tRNA synthetase; Identified by similarity to SP:P21888; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.709 |
| dksA | cysS | SPO2511 | SPO2131 | dnaK suppressor protein, putative; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | cysteinyl-tRNA synthetase; Identified by similarity to SP:P21888; match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.409 |
| dksA | rrmJ | SPO2511 | SPO1858 | dnaK suppressor protein, putative; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.460 |
| dksA | trmJ | SPO2511 | SPO2055 | dnaK suppressor protein, putative; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.492 |
| pncA | trmJ | SPO0093 | SPO2055 | Pyrazinamidase/nicotinamidase; Identified by similarity to SP:P21369; match to protein family HMM PF00857. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.614 |
| rnhB | trmJ | SPO3452 | SPO2055 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.551 |
| rrmJ | dksA | SPO1858 | SPO2511 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | dnaK suppressor protein, putative; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. | 0.460 |
| rrmJ | trmJ | SPO1858 | SPO2055 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.593 |