STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisA2Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, putative; Identified by similarity to SP:P26720; match to protein family HMM PF00977. (247 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
 0.998
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.997
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.995
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by similarity to SP:P18787; match to protein family HMM PF00475.
 
  
 0.975
hisE
phosphoribosyl-ATP pyrophosphohydrolase; Identified by match to protein family HMM PF01503.
 
  
 0.957
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:P26720; match to protein family HMM PF00977; match to protein family HMM TIGR00007.
  
  
 
0.913
SPO0981
Histidinol dehydrogenase, putative; Identified by match to protein family HMM PF00815.
 
  
 0.909
hpsN
Dihydroxypropanesulfonate-3-dehydrogenase; Catalyzes the NAD-dependent oxidation of (R)-2,3- dihydroxypropane-1-sulfonate to (R)-3-sulfolactate.
 
  
 0.896
SPO0669
ATP phosphoribosyltransferase, putative; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.883
SPO0668
histidyl-tRNA synthetase-like protein; Identified by similarity to SP:P56194.
  
  
 0.848
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.