| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO2469 | SPO3203 | SPO2469 | SPO3203 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.930 |
| SPO2469 | SPO3541 | SPO2469 | SPO3541 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | 0.909 |
| SPO2469 | hpt | SPO2469 | SPO2097 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37171; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.911 |
| SPO2469 | pncB | SPO2469 | SPO0095 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.916 |
| SPO2469 | pyrG | SPO2469 | SPO1312 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.911 |
| SPO2469 | sthA | SPO2469 | SPO3828 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Soluble pyridine nucleotide transhydrogenase; Identified by similarity to SP:P27306; match to protein family HMM PF00070; match to protein family HMM PF02852. | 0.908 |
| SPO2469 | surE | SPO2469 | SPO2688 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
| SPO2469 | thyX | SPO2469 | SPO1273 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.942 |
| SPO2469 | tmk | SPO2469 | SPO2740 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.921 |
| SPO2469 | upp | SPO2469 | SPO2926 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.909 |
| SPO3203 | SPO2469 | SPO3203 | SPO2469 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.930 |
| SPO3541 | SPO2469 | SPO3541 | SPO2469 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.909 |
| SPO3541 | pncB | SPO3541 | SPO0095 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.911 |
| SPO3541 | sthA | SPO3541 | SPO3828 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Soluble pyridine nucleotide transhydrogenase; Identified by similarity to SP:P27306; match to protein family HMM PF00070; match to protein family HMM PF02852. | 0.900 |
| SPO3541 | surE | SPO3541 | SPO2688 | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
| hpt | SPO2469 | SPO2097 | SPO2469 | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37171; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.911 |
| hpt | surE | SPO2097 | SPO2688 | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37171; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
| hpt | upp | SPO2097 | SPO2926 | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37171; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.567 |
| pncB | SPO2469 | SPO0095 | SPO2469 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.916 |
| pncB | SPO3541 | SPO0095 | SPO3541 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. | 0.911 |