| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO2228 | glnE | SPO2228 | SPO2523 | Identified by match to protein family HMM PF00578. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.674 |
| SPO2520 | SPO2521 | SPO2520 | SPO2521 | Hypothetical protein; Identified by similarity to PIR:D83601. | Lipoprotein, putative. | 0.733 |
| SPO2520 | SPO2522 | SPO2520 | SPO2522 | Hypothetical protein; Identified by similarity to PIR:D83601. | Hypothetical protein; Identified by Glimmer2; putative. | 0.462 |
| SPO2520 | glnE | SPO2520 | SPO2523 | Hypothetical protein; Identified by similarity to PIR:D83601. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.538 |
| SPO2521 | SPO2520 | SPO2521 | SPO2520 | Lipoprotein, putative. | Hypothetical protein; Identified by similarity to PIR:D83601. | 0.733 |
| SPO2521 | SPO2522 | SPO2521 | SPO2522 | Lipoprotein, putative. | Hypothetical protein; Identified by Glimmer2; putative. | 0.497 |
| SPO2521 | glnE | SPO2521 | SPO2523 | Lipoprotein, putative. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.497 |
| SPO2522 | SPO2520 | SPO2522 | SPO2520 | Hypothetical protein; Identified by Glimmer2; putative. | Hypothetical protein; Identified by similarity to PIR:D83601. | 0.462 |
| SPO2522 | SPO2521 | SPO2522 | SPO2521 | Hypothetical protein; Identified by Glimmer2; putative. | Lipoprotein, putative. | 0.497 |
| SPO2522 | SPO2524 | SPO2522 | SPO2524 | Hypothetical protein; Identified by Glimmer2; putative. | YbaK/prolyl-tRNA synthetases domain protein; Identified by match to protein family HMM PF04073. | 0.680 |
| SPO2522 | glnE | SPO2522 | SPO2523 | Hypothetical protein; Identified by Glimmer2; putative. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.845 |
| SPO2524 | SPO2522 | SPO2524 | SPO2522 | YbaK/prolyl-tRNA synthetases domain protein; Identified by match to protein family HMM PF04073. | Hypothetical protein; Identified by Glimmer2; putative. | 0.680 |
| SPO2524 | glnE | SPO2524 | SPO2523 | YbaK/prolyl-tRNA synthetases domain protein; Identified by match to protein family HMM PF04073. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.687 |
| glnA | glnE | SPO2295 | SPO2523 | Glutamine synthetase, type I; Identified by similarity to SP:P06201; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.520 |
| glnA | gltB | SPO2295 | SPO3768 | Glutamine synthetase, type I; Identified by similarity to SP:P06201; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Glutamate synthase, large subunit; Identified by similarity to SP:Q05755; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898. | 0.966 |
| glnD | glnE | SPO0397 | SPO2523 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.805 |
| glnD | gltB | SPO0397 | SPO3768 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Glutamate synthase, large subunit; Identified by similarity to SP:Q05755; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898. | 0.661 |
| glnD | ntrB | SPO0397 | SPO2088 | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | Nitrogen regulation protein NtrB; Identified by similarity to SP:P09431; match to protein family HMM PF00512; match to protein family HMM PF02518. | 0.573 |
| glnE | SPO2228 | SPO2523 | SPO2228 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Identified by match to protein family HMM PF00578. | 0.674 |
| glnE | SPO2520 | SPO2523 | SPO2520 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein; Identified by similarity to PIR:D83601. | 0.538 |
