Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemA-15-aminolevulinic acid synthase; Identified by match to protein family HMM PF00155; match to protein family HMM PF02490; match to protein family HMM TIGR01821. (407 aa)    
Predicted Functional Partners:
SPO2345
Sarcosine oxidase, alpha subunit family; Identified by similarity to SP:Q46337; match to protein family HMM PF01571; match to protein family HMM TIGR01372; Belongs to the GcvT family.
  
 
 0.927
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
  
 
0.920
hemB
Porphobilinogen synthase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family.
    
 0.919
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.912
SPO3156
L-threonine aldolase, low-specificity, putative; Identified by similarity to SP:O50584.
  
 
 0.912
glyA-1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.911
glyA-3
Serine hydroxymethyltransferase; Identified by match to protein family HMM PF00464.
  
 
 0.911
SPO3029
Serine--glyoxylate transaminase, putative; Identified by similarity to SP:O08374; match to protein family HMM PF00266.
    
 0.906
SPO2348
Sarcosine oxidase, beta subunit family; Identified by similarity to SP:P40875; match to protein family HMM PF01266; match to protein family HMM TIGR01373.
  
 
 0.904
SPO2344
Sarcosine oxidase, gamma subunit family; Identified by similarity to SP:Q46338; match to protein family HMM PF04268.
     
  0.900
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.