STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPO28593-hydroxyisobutyrate dehydrogenase family protein; Identified by similarity to SP:P23523. (320 aa)    
Predicted Functional Partners:
mmsA
Methylmalonate-semialdehyde dehydrogenase; Identified by similarity to SP:P28810; match to protein family HMM PF00171; match to protein family HMM TIGR01722.
 
 
 0.930
SPO0792
6-phosphogluconate dehydrogenase domain protein; Identified by match to protein family HMM PF03446; match to protein family HMM TIGR00872; match to protein family HMM TIGR00873.
  
 
 
0.927
mmsB-1
3-hydroxyisobutyrate dehydrogenase; Identified by similarity to SP:P28811; match to protein family HMM PF03446; match to protein family HMM TIGR01692; Belongs to the HIBADH-related family.
  
  
 
0.922
SPO0097
Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family.
  
 
 0.914
SPO3368
Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family.
  
 
 0.914
SPO3382
Identified by match to protein family HMM PF00171.
  
 
 0.914
pccA
propionyl-CoA carboxylase, alpha subunit; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (Probable).
  
 
  0.834
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.818
acsA
Acetyl-coenzyme A synthetase; Identified by similarity to SP:P39062; match to protein family HMM PF00501.
  
 
 0.818
prpE
propionate--CoA ligase; Identified by similarity to SP:P77495; match to protein family HMM PF00501.
  
 
 0.818
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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