STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPO3156L-threonine aldolase, low-specificity, putative; Identified by similarity to SP:O50584. (345 aa)    
Predicted Functional Partners:
thrC
Threonine synthase; Identified by similarity to GB:CAA82670.1; match to protein family HMM PF00291; match to protein family HMM TIGR00260.
 
 
 0.938
glyA-1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.923
glyA-3
Serine hydroxymethyltransferase; Identified by match to protein family HMM PF00464.
   
 0.923
SPO2344
Sarcosine oxidase, gamma subunit family; Identified by similarity to SP:Q46338; match to protein family HMM PF04268.
 
  
  0.920
SPO2346
Sarcosine oxidase, delta subunit family; Identified by similarity to SP:Q46336; match to protein family HMM PF04267.
 
  
  0.920
SPO2345
Sarcosine oxidase, alpha subunit family; Identified by similarity to SP:Q46337; match to protein family HMM PF01571; match to protein family HMM TIGR01372; Belongs to the GcvT family.
   
 0.913
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.912
SPO1142
Threonine dehydratase, putative; Identified by match to protein family HMM PF00291.
  
 
 0.912
hemA-1
5-aminolevulinic acid synthase; Identified by match to protein family HMM PF00155; match to protein family HMM PF02490; match to protein family HMM TIGR01821.
  
 
 0.912
SPO3341
Pyridoxal-phosphate dependent enzyme family protein; Identified by match to protein family HMM PF00291.
  
 
 0.912
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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