| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPO2024 | cysE | SPO2024 | SPO2247 | Aminotransferase; 'initially identified as a pseudogene, expression verified by proteomics'. | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 0.491 |
| SPO2024 | nadA | SPO2024 | SPO3243 | Aminotransferase; 'initially identified as a pseudogene, expression verified by proteomics'. | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.550 |
| SPO2024 | nadC | SPO2024 | SPO3245 | Aminotransferase; 'initially identified as a pseudogene, expression verified by proteomics'. | Nicotinate-nucleotide pyrophosphorylase; Identified by similarity to SP:P39666; match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; Belongs to the NadC/ModD family. | 0.485 |
| SPO3244 | nadA | SPO3244 | SPO3243 | L-aspartate oxidase, putative; Identified by similarity to GB:BAB54506.1; match to protein family HMM PF00890; match to protein family HMM PF02910. | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.999 |
| SPO3244 | nadC | SPO3244 | SPO3245 | L-aspartate oxidase, putative; Identified by similarity to GB:BAB54506.1; match to protein family HMM PF00890; match to protein family HMM PF02910. | Nicotinate-nucleotide pyrophosphorylase; Identified by similarity to SP:P39666; match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; Belongs to the NadC/ModD family. | 0.999 |
| SPO3244 | nadE | SPO3244 | SPO0426 | L-aspartate oxidase, putative; Identified by similarity to GB:BAB54506.1; match to protein family HMM PF00890; match to protein family HMM PF02910. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.613 |
| SPO3244 | nadX | SPO3244 | SPO2880 | L-aspartate oxidase, putative; Identified by similarity to GB:BAB54506.1; match to protein family HMM PF00890; match to protein family HMM PF02910. | Hypothetical protein; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. | 0.909 |
| cysE | SPO2024 | SPO2247 | SPO2024 | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Aminotransferase; 'initially identified as a pseudogene, expression verified by proteomics'. | 0.491 |
| cysE | ispDF | SPO2247 | SPO2090 | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.489 |
| cysE | nadA | SPO2247 | SPO3243 | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.829 |
| cysE | nadE | SPO2247 | SPO0426 | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.462 |
| cysE | ribD | SPO2247 | SPO1754 | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.434 |
| gmk | ispDF | SPO1945 | SPO2090 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.428 |
| gmk | nadA | SPO1945 | SPO3243 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.778 |
| gmk | ribD | SPO1945 | SPO1754 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.661 |
| ispDF | cysE | SPO2090 | SPO2247 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Serine O-acetyltransferase; Identified by similarity to SP:P05796; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. | 0.489 |
| ispDF | gmk | SPO2090 | SPO1945 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.428 |
| ispDF | nadA | SPO2090 | SPO3243 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.507 |
| ispDF | nadE | SPO2090 | SPO0426 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.542 |
| ispDF | ribD | SPO2090 | SPO1754 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.661 |