node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SPO0092 | SPO3038 | SPO0092 | SPO3038 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | 0.511 |
SPO0092 | SPO3904 | SPO0092 | SPO3904 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Heat shock protein; 'initially identified as a pseudogene, expression verified by proteomics'; Belongs to the small heat shock protein (HSP20) family. | 0.468 |
SPO0092 | clpB | SPO0092 | SPO3276 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.911 |
SPO0092 | clpP | SPO0092 | SPO1003 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.688 |
SPO0092 | dnaJ | SPO0092 | SPO0044 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.941 |
SPO0092 | groES | SPO0092 | SPO0886 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.877 |
SPO0092 | grpE | SPO0092 | SPO0010 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.962 |
SPO0092 | hslV | SPO0092 | SPO3880 | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | ATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.501 |
SPO3038 | SPO0092 | SPO3038 | SPO0092 | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | 0.511 |
SPO3038 | clpB | SPO3038 | SPO3276 | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.705 |
SPO3038 | clpP | SPO3038 | SPO1003 | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.452 |
SPO3038 | dnaJ | SPO3038 | SPO0044 | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.400 |
SPO3038 | dnaK | SPO3038 | SPO0043 | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.511 |
SPO3904 | SPO0092 | SPO3904 | SPO0092 | Heat shock protein; 'initially identified as a pseudogene, expression verified by proteomics'; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | 0.468 |
SPO3904 | clpB | SPO3904 | SPO3276 | Heat shock protein; 'initially identified as a pseudogene, expression verified by proteomics'; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.736 |
SPO3904 | dnaK | SPO3904 | SPO0043 | Heat shock protein; 'initially identified as a pseudogene, expression verified by proteomics'; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.523 |
SPO3904 | grpE | SPO3904 | SPO0010 | Heat shock protein; 'initially identified as a pseudogene, expression verified by proteomics'; Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.451 |
SPO3904 | hslV | SPO3904 | SPO3880 | Heat shock protein; 'initially identified as a pseudogene, expression verified by proteomics'; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.426 |
clpB | SPO0092 | SPO3276 | SPO0092 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein, Hsp70 family; Identified by similarity to SP:P36928. | 0.911 |
clpB | SPO3038 | SPO3276 | SPO3038 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. | 0.705 |