STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (347 aa)    
Predicted Functional Partners:
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
 
 0.997
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 0.910
SPO1142
Threonine dehydratase, putative; Identified by match to protein family HMM PF00291.
   
 0.910
SPO3341
Pyridoxal-phosphate dependent enzyme family protein; Identified by match to protein family HMM PF00291.
   
 0.910
thrC
Threonine synthase; Identified by similarity to GB:CAA82670.1; match to protein family HMM PF00291; match to protein family HMM TIGR00260.
   
 
 0.904
SPO3156
L-threonine aldolase, low-specificity, putative; Identified by similarity to SP:O50584.
    
 0.903
hemA-1
5-aminolevulinic acid synthase; Identified by match to protein family HMM PF00155; match to protein family HMM PF02490; match to protein family HMM TIGR01821.
  
 0.614
SPO0791
M23/M37 peptidase/aminotransferase, class III; Identified by match to protein family HMM PF00202; match to protein family HMM PF01551.
  
 
 0.548
SPO3361
RmuC domain protein; Identified by similarity to GB:BAB51420.1; match to protein family HMM PF02646.
       0.533
SPO0849
Non-ribosomal peptide synthase; Identified by similarity to GB:CAD70195.1; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF00975; match to protein family HMM PF02801.
  
  
 0.492
Your Current Organism:
Ruegeria pomeroyi
NCBI taxonomy Id: 246200
Other names: R. pomeroyi DSS-3, Ruegeria pomeroyi DSS-3, Ruegeria pomeroyi str. DSS-3, Ruegeria pomeroyi strain DSS-3, Silicibacter pomeroyi DSS-3
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