node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIMG06451 | CIMG_00809 | A0A0D8JTW2 | J3KHT5 | ATP-dependent DNA ligase. | High-affinity nickel transporter. | 0.774 |
CIMG06451 | CIMG_01943 | A0A0D8JTW2 | J3KKA5 | ATP-dependent DNA ligase. | Exosome complex exonuclease Rrp6. | 0.466 |
CIMG06451 | CIMG_04365 | A0A0D8JTW2 | J3KDB7 | ATP-dependent DNA ligase. | Phosphatidylinositol 3-kinase tor2; Belongs to the PI3/PI4-kinase family. | 0.466 |
CIMG06451 | CIMG_05525 | A0A0D8JTW2 | J3KFS4 | ATP-dependent DNA ligase. | Exonuclease. | 0.728 |
CIMG06451 | FEN1 | A0A0D8JTW2 | A0A0E1RY46 | ATP-dependent DNA ligase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.893 |
CIMG06451 | KU70 | A0A0D8JTW2 | Q1DU75 | ATP-dependent DNA ligase. | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. I [...] | 0.756 |
CIMG06451 | KU80 | A0A0D8JTW2 | Q1E6K9 | ATP-dependent DNA ligase. | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. I [...] | 0.795 |
CIMG06451 | LIG4 | A0A0D8JTW2 | Q1DKE7 | ATP-dependent DNA ligase. | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. | 0.919 |
CIMG_00809 | CIMG06451 | J3KHT5 | A0A0D8JTW2 | High-affinity nickel transporter. | ATP-dependent DNA ligase. | 0.774 |
CIMG_00809 | CIMG_01943 | J3KHT5 | J3KKA5 | High-affinity nickel transporter. | Exosome complex exonuclease Rrp6. | 0.401 |
CIMG_00809 | CIMG_04365 | J3KHT5 | J3KDB7 | High-affinity nickel transporter. | Phosphatidylinositol 3-kinase tor2; Belongs to the PI3/PI4-kinase family. | 0.401 |
CIMG_00809 | CIMG_04936 | J3KHT5 | J3KEJ0 | High-affinity nickel transporter. | DNA repair protein. | 0.693 |
CIMG_00809 | CIMG_05525 | J3KHT5 | J3KFS4 | High-affinity nickel transporter. | Exonuclease. | 0.838 |
CIMG_00809 | FEN1 | J3KHT5 | A0A0E1RY46 | High-affinity nickel transporter. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.941 |
CIMG_00809 | KU70 | J3KHT5 | Q1DU75 | High-affinity nickel transporter. | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. I [...] | 0.857 |
CIMG_00809 | KU80 | J3KHT5 | Q1E6K9 | High-affinity nickel transporter. | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. I [...] | 0.834 |
CIMG_00809 | LIG4 | J3KHT5 | Q1DKE7 | High-affinity nickel transporter. | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. | 0.873 |
CIMG_01943 | CIMG06451 | J3KKA5 | A0A0D8JTW2 | Exosome complex exonuclease Rrp6. | ATP-dependent DNA ligase. | 0.466 |
CIMG_01943 | CIMG_00809 | J3KKA5 | J3KHT5 | Exosome complex exonuclease Rrp6. | High-affinity nickel transporter. | 0.401 |
CIMG_01943 | CIMG_04936 | J3KKA5 | J3KEJ0 | Exosome complex exonuclease Rrp6. | DNA repair protein. | 0.582 |