STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
L8YAE7_TUPCHToll-interacting protein. (254 aa)    
Predicted Functional Partners:
L9KL93_TUPCH
Interleukin-1 receptor-associated kinase-like 2.
   
 0.917
IRAK4
Interleukin-1 receptor-associated kinase 4.
   
 0.874
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.842
L8YG62_TUPCH
TOM1-like protein 2; Belongs to the TOM1 family.
    
 
 0.810
L8YB37_TUPCH
Interleukin-1 receptor-like 2.
    
 0.751
L9JK57_TUPCH
Interleukin-1 receptor accessory protein.
    
 0.687
L9L6M2_TUPCH
Toll-like receptor 4.
    
 
 0.648
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
 
 0.639
ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial.
    
 
 0.634
L9KW49_TUPCH
Interleukin-1 receptor-associated kinase 3.
   
 0.605
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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