STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEDD4LE3 ubiquitin-protein ligase NEDD4-like protein. (201 aa)    
Predicted Functional Partners:
SFN
14-3-3 protein sigma; Belongs to the 14-3-3 family.
    
 0.925
SGK1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.918
SCNN1G
Amiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
  0.914
CBL
E3 ubiquitin-protein ligase CBL.
    
 0.913
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
  0.904
ITCH
E3 ubiquitin-protein ligase Itchy like protein.
     
 
0.900
L9LG18_TUPCH
E3 ubiquitin-protein ligase NEDD4-like protein.
 
      0.899
L8Y7L8_TUPCH
E3 ubiquitin-protein ligase HUWE1.
 
  
 0.579
UBA52
Ubiquitin-60S ribosomal protein L40.
    
 0.576
L9JIK0_TUPCH
NEDD4-like E3 ubiquitin-protein ligase WWP2.
 
      0.519
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.