STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADNPActivity-dependent neuroprotector homeobox protein. (1190 aa)    
Predicted Functional Partners:
CHD4
Chromodomain-helicase-DNA-binding protein 4.
   
 
 0.710
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 
 0.603
L9L296_TUPCH
Nucleosome-remodeling factor subunit BPTF.
   
  
 0.530
TRIP12
Putative E3 ubiquitin-protein ligase TRIP12.
   
  
 0.515
CBX3
Chromobox protein like protein 3.
    
 
 0.501
L9KMP4_TUPCH
Putative histone-lysine N-methyltransferase ASH1L.
   
 
 0.426
L9KQZ1_TUPCH
Chromodomain-helicase-DNA-binding protein 3.
   
 
 0.401
L9L0Y3_TUPCH
Chromodomain-helicase-DNA-binding protein 5.
   
 
 0.401
Your Current Organism:
Tupaia chinensis
NCBI taxonomy Id: 246437
Other names: Chinese tree shrew, T. chinensis, Tupaia belangeri chinensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.