node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERBB2 | IGF1 | L9JWC4 | L9L9F0 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I. | 0.953 |
ERBB2 | INS | L9JWC4 | L9LDU9 | Receptor protein-tyrosine kinase. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.934 |
ERBB2 | IRS1 | L9JWC4 | L9LBX5 | Receptor protein-tyrosine kinase. | Insulin receptor substrate 1. | 0.916 |
ERBB2 | L8Y6N1_TUPCH | L9JWC4 | L8Y6N1 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.492 |
ERBB2 | PDGFRA | L9JWC4 | L9L577 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.928 |
ERBB2 | PDGFRB | L9JWC4 | L9KPB8 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.945 |
ERBB2 | TGFA | L9JWC4 | L9KS92 | Receptor protein-tyrosine kinase. | Protransforming growth factor alpha. | 0.981 |
IGF1 | ERBB2 | L9L9F0 | L9JWC4 | Insulin-like growth factor I. | Receptor protein-tyrosine kinase. | 0.953 |
IGF1 | INS | L9L9F0 | L9LDU9 | Insulin-like growth factor I. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.958 |
IGF1 | IRS1 | L9L9F0 | L9LBX5 | Insulin-like growth factor I. | Insulin receptor substrate 1. | 0.512 |
IGF1 | IRS4 | L9L9F0 | L9L5W9 | Insulin-like growth factor I. | Insulin receptor substrate 4. | 0.512 |
IGF1 | KIT | L9L9F0 | L9L582 | Insulin-like growth factor I. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.763 |
IGF1 | L8Y6N1_TUPCH | L9L9F0 | L8Y6N1 | Insulin-like growth factor I. | Tyrosine-protein kinase receptor. | 0.967 |
IGF1 | PDGFRA | L9L9F0 | L9L577 | Insulin-like growth factor I. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.930 |
IGF1 | PDGFRB | L9L9F0 | L9KPB8 | Insulin-like growth factor I. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.937 |
IGF1 | TGFA | L9L9F0 | L9KS92 | Insulin-like growth factor I. | Protransforming growth factor alpha. | 0.942 |
INS | ERBB2 | L9LDU9 | L9JWC4 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Receptor protein-tyrosine kinase. | 0.934 |
INS | IGF1 | L9LDU9 | L9L9F0 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin-like growth factor I. | 0.958 |
INS | IRS1 | L9LDU9 | L9LBX5 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin receptor substrate 1. | 0.970 |
INS | IRS4 | L9LDU9 | L9L5W9 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin receptor substrate 4. | 0.970 |